Sulpiride: A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain

M. Trabucchi, R. Longoni, P. Fresia, P. F. Spano

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Sulpiride is a new neuroleptic which does not produce extrapyramidal side effects in humans nor catalepsy in experimental animals. Sulpiride in rat striatum and nucleus accumbens homogenates fails to block adenylate cyclase activation induced by both dopamine and apomorphine. Moreover the in vivo cyclic adenosine monophosphate accumulation induced by apomorphine in the striatum of rats is not blocked by sulpiride as haloperidol and other classic neuroleptic do. Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.

Original languageEnglish
Pages (from-to)1551-1556
Number of pages6
JournalLife Sciences
Volume17
Issue number10
DOIs
Publication statusPublished - Nov 15 1975

Fingerprint

Neostriatum
Sulpiride
Dopamine Receptors
Prosencephalon
Rats
Antipsychotic Agents
Apomorphine
Catalepsy
Nucleus Accumbens
Haloperidol
Adenylyl Cyclases
Cyclic AMP
Dopamine
Animals
Chemical activation
Experiments

ASJC Scopus subject areas

  • Pharmacology

Cite this

Sulpiride : A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain. / Trabucchi, M.; Longoni, R.; Fresia, P.; Spano, P. F.

In: Life Sciences, Vol. 17, No. 10, 15.11.1975, p. 1551-1556.

Research output: Contribution to journalArticle

Trabucchi, M. ; Longoni, R. ; Fresia, P. ; Spano, P. F. / Sulpiride : A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain. In: Life Sciences. 1975 ; Vol. 17, No. 10. pp. 1551-1556.
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