Abstract
Sulpiride is a new neuroleptic which does not produce extrapyramidal side effects in humans nor catalepsy in experimental animals. Sulpiride in rat striatum and nucleus accumbens homogenates fails to block adenylate cyclase activation induced by both dopamine and apomorphine. Moreover the in vivo cyclic adenosine monophosphate accumulation induced by apomorphine in the striatum of rats is not blocked by sulpiride as haloperidol and other classic neuroleptic do. Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1551-1556 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 17 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 15 1975 |
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ASJC Scopus subject areas
- Pharmacology
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Sulpiride : A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain. / Trabucchi, M.; Longoni, R.; Fresia, P.; Spano, P. F.
In: Life Sciences, Vol. 17, No. 10, 15.11.1975, p. 1551-1556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sulpiride
T2 - A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain
AU - Trabucchi, M.
AU - Longoni, R.
AU - Fresia, P.
AU - Spano, P. F.
PY - 1975/11/15
Y1 - 1975/11/15
N2 - Sulpiride is a new neuroleptic which does not produce extrapyramidal side effects in humans nor catalepsy in experimental animals. Sulpiride in rat striatum and nucleus accumbens homogenates fails to block adenylate cyclase activation induced by both dopamine and apomorphine. Moreover the in vivo cyclic adenosine monophosphate accumulation induced by apomorphine in the striatum of rats is not blocked by sulpiride as haloperidol and other classic neuroleptic do. Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.
AB - Sulpiride is a new neuroleptic which does not produce extrapyramidal side effects in humans nor catalepsy in experimental animals. Sulpiride in rat striatum and nucleus accumbens homogenates fails to block adenylate cyclase activation induced by both dopamine and apomorphine. Moreover the in vivo cyclic adenosine monophosphate accumulation induced by apomorphine in the striatum of rats is not blocked by sulpiride as haloperidol and other classic neuroleptic do. Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016676004&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(75)90176-9
DO - 10.1016/0024-3205(75)90176-9
M3 - Article
C2 - 173950
AN - SCOPUS:0016676004
VL - 17
SP - 1551
EP - 1556
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 10
ER -