Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity: A possible involvement of prolactin

Ferdinando Nicoletti, Pier Luigi Canonico, Francesco Patti, Liborio Rampello, Daniele Filippo Condorelli, Giovanni Giammona, Rosa Maria Di Giorgio, Umberto Scapagnini

Research output: Contribution to journalArticle

Abstract

Sulpiride, a benzamide derivative neuroleptic, was shown to significantly increase glutamic acid decarboxylase activity in substantia nigra and corpus striatum in either acutely or chronically injected male rats. Hypophysectomy completely prevented this effect suggesting an involvement of an anterior pituitary factor in the central action of sulpiride. Prolactin might possibly mediate the effects of sulpiride since it is known to increase prolactin secretion by an action at the level of the anterior pituitary. Consistent with this hypothesis was the finding of a similar increase in nigral and striatal glutamic acid decarboxylase activity in hyperprolactinemic animals in which an anterior pituitary had been implanted under the kidney capsule.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalEuropean Journal of Pharmacology
Volume77
Issue number2-3
DOIs
Publication statusPublished - Jan 22 1982

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Keywords

  • Corpus striatum
  • Glutamic acid decarboxylase activity
  • Prolactin
  • Substantia nigra
  • Sulpiride

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Nicoletti, F., Canonico, P. L., Patti, F., Rampello, L., Condorelli, D. F., Giammona, G., Di Giorgio, R. M., & Scapagnini, U. (1982). Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity: A possible involvement of prolactin. European Journal of Pharmacology, 77(2-3), 131-135. https://doi.org/10.1016/0014-2999(82)90007-3