Sumatriptan in migraine with unilateral cranial autonomic symptoms: An open study

Piero Barbanti, Giovanni Fabbrini, Nicola Vanacore, Marina Pesare, Maria Gabriella Buzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. - To investigate the response to sumatriptan in migraineurs with unilateral cranial autonomic symptoms such as lacrimation, eye redness, eyelid edema, nasal congestion, and rhinorrhea. Background. - Given the potential large-scale recruitment of peripheral neurovascular 5-HT1B/1D receptors consequent to the activation of the trigeminal autonomic reflex in such patients, the presence of unilateral cranial autonomic symptoms may predict a positive response to sumatriptan. Methods. - Seventy-two consecutive migraineurs with unilateral cranial autonomic symptoms were given sumatriptan 50-mg tablets to treat 1 migraine attack and were asked to record their clinical response to the drug at different time points. End points were pain-relief and pain-free response at 1 and 2 hours. Results. - Pain relief was reported by 47 patients (65.3%) at 1 hour and by 59 (81.9%) at 2 hours. Pain-free response was reported by 22 patients (30.6%) at 1 hour and by 44 (61.1%) at 2 hours. Responsiveness to sumatriptan did not correlate with the type or number of unilateral cranial autonomic symptoms, demographic characteristics, prophylactic treatments, use of contraceptives, or concomitant tension-type headache. Conclusions. - Migraineurs with unilateral cranial autonomic symptoms seem to respond to sumatriptan better than other migraineurs. The presence of unilateral cranial autonomic symptoms may predict a positive response to the triptans.

Original languageEnglish
Pages (from-to)400-403
Number of pages4
JournalHeadache
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Autonomic symptoms
  • Migraine
  • Sumatriptan
  • Trigeminal autonomic reflex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Sumatriptan in migraine with unilateral cranial autonomic symptoms: An open study'. Together they form a unique fingerprint.

Cite this