Sumo paralogs: Redundancy and divergencies

Research output: Contribution to journalArticle

Abstract

Although sharing a common conjugation pathway, SUMO1, SUMO2/3 and SUMO4 seem to play preferential roles in the cell. Recently, many regulatory mechanisms contributing to SUMO paralogs specific modification have emerged. SUMO enzymes can discriminate between SUMO paralogs at both conjugation and deconjugation levels. Moreover, many substrates possess characteristics that promote their preference for different SUMO family members. A better knowledge of the mechanisms promoting SUMO specific modification will improve our understanding of the functions of SUMO paralogs in distinct cellular pathways.

Original languageEnglish
Pages (from-to)544-553
Number of pages10
JournalFrontiers in Bioscience - Scholar
Volume5 S
Issue number2
Publication statusPublished - Jan 1 2013

Keywords

  • Desumoylases
  • E3 ligases
  • Paralog specificity
  • Review
  • SIMs
  • SUMO1
  • SUMO2/3
  • SUMO4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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