SUMO Ubc9 enzyme as a viral target

Archana Varadaraj, Domenico Mattoscio, Susanna Chiocca

Research output: Contribution to journalArticle

Abstract

Viruses alter specific host cell targets to counteract possible defense mechanisms aimed at eliminating infectivity and viral propagation. The SUMO conjugating enzyme Ubc9 functions as a hub for protein sumoylation, whilst also providing an interactive surface for sumoylated proteins through noncovalent interactions. The targeting of Ubc9 by viruses and viral proteins is thus highly beneficial for the disruption of both protein modification and protein-protein interaction mechanisms with which proteins increase their functional repertoire in cells. This review explores some of the clever mechanisms adopted by viruses to deregulate Ubc9, influence effector pathways and positively impact viral persistence consequently.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalIUBMB Life
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • SUMO
  • SUMO UBC9 enzyme
  • viral proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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