SUNCT syndrome with paroxysmal mydriasis: Clinical and pupillometric findings

F. Antonaci, G. Sances, M. Loi, G. Sandrini, C. Dumitrache, M. G. Cuzzoni

Research output: Contribution to journalArticlepeer-review


SUNCT syndrome (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) is a primary headache characterised by a high frequency of attacks associated with marked autonomic periocular signs and symptoms. Activation of the hypothalamus via the superior salivary nucleus is probably responsible for some of the autonomic involvement observed during SUNCTattacks.We describe a case of SUNCTwith unusual autonomic features (e.g., mydriasis) and early onset. Pupillometric studies were performed both in a basal condition (without anisocoria) and after instillation of phenylephrine (a drug with direct sympathomimetic activity) and pilocarpine (a parasympathetic agonist). The findings in this patient seem to indicate involvement of the ocular sympathetic supply in SUNCT, responsible for the mydriasis, and seem to strengthen the possibility that the autonomic phenomena in this syndrome vary with different levels of pain severity.

Original languageEnglish
Pages (from-to)987-990
Number of pages4
Issue number8
Publication statusPublished - Aug 2010


  • Autonomic features
  • Pathophysiology
  • Pupillometry
  • SUNCT syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)


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