TY - JOUR
T1 - Sunitinib in malignant melanoma
T2 - a treatment option only for KIT-mutated patients?
AU - Santini, Daniele
AU - Vincenzi, Bruno
AU - Venditti, Olga
AU - Dell'Aquila, Emanuela
AU - Frezza, Anna Maria
AU - Silletta, Marianna
AU - Guida, Francesco Maria
AU - Grasso, Rosario Francesco
AU - Silvestris, Nicola
AU - Lanzetta, Gaetano
AU - Tonini, Giuseppe
PY - 2013/12
Y1 - 2013/12
N2 - Sunitinib has previously been reported to be potentially effective in the treatment of malignant melanomas expressing c-KIT. Here we report on the case of a 77-year-old gentleman affected by a metastatic clear cell carcinoma of the kidney and a metastatic malignant melanoma with liver and lung metastases. Despite the negativity for CD117 and the absence of KIT amplification or mutations in the melanoma specimen, he achieved a partial response both in the lungs and in the liver while on sunitinib (50 mg once/day, 4 weeks on/2 weeks off) for the treatment of kidney cancer. To our knowledge, this represents the first evidence of sunitinib activity in KIT wild-type melanoma. Further studies should be performed to confirm these preliminary data.
AB - Sunitinib has previously been reported to be potentially effective in the treatment of malignant melanomas expressing c-KIT. Here we report on the case of a 77-year-old gentleman affected by a metastatic clear cell carcinoma of the kidney and a metastatic malignant melanoma with liver and lung metastases. Despite the negativity for CD117 and the absence of KIT amplification or mutations in the melanoma specimen, he achieved a partial response both in the lungs and in the liver while on sunitinib (50 mg once/day, 4 weeks on/2 weeks off) for the treatment of kidney cancer. To our knowledge, this represents the first evidence of sunitinib activity in KIT wild-type melanoma. Further studies should be performed to confirm these preliminary data.
UR - http://www.scopus.com/inward/record.url?scp=84903680350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903680350&partnerID=8YFLogxK
M3 - Article
C2 - 24295410
AN - SCOPUS:84903680350
VL - 9
SP - 1809
EP - 1811
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 12
ER -