Abstract
Background: To report on sunitinib activity in a retrospective series of 35 solitary fibrous tumor (SFT) treated at a single institution. Patients and methods: From April 2008, 35 patients with progressive advanced SFT (male/female: 20/15; mean age: 58 years; meningeal/extrameningeal: 6/29; locally advanced/metastatic: 15/20; prior chemotherapy: 25) were treated, on an individual use basis, with continuous-dosing sunitinib 37.5 mg/day. Platelet-derived growth factor receptor beta (PDGFRB) and vascular endothelial growth factor receptor 2 (VEGFR2) status were assessed by immunohistochemistry and, in a subgroup of patients, by real time PCR. Results: Thirty-one patients were assessable for response by RECIST (one early death; three early interruptions). Best responses were 2 partial response (PR), 16 stable disease, 13 progressive disease. A
Original language | English |
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Article number | mds143 |
Pages (from-to) | 3171-3179 |
Number of pages | 9 |
Journal | Annals of Oncology |
Volume | 23 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2012 |
Keywords
- Chemotherapy
- Hemangioperycitoma
- Sarcoma
- Solitary fibrous tumor
- Sunitinib
- Tyrosine kinase inhibitors
ASJC Scopus subject areas
- Oncology
- Hematology