Abstract
The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas. Methods: Fourteen patients were evaluated. After 111Inpentetreotide injection (~250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients. Results: SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings. Conclusion: SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.
| Original language | English |
|---|---|
| Pages (from-to) | 459-462 |
| Number of pages | 4 |
| Journal | Journal of Nuclear Medicine |
| Volume | 41 |
| Issue number | 3 |
| Publication status | Published - 2000 |
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Keywords
- Insulinomas
- Somatostatin receptor scintigraphy
- SPECT
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
111In-pentetreotide scintigraphy in the detection of insulinomas : Importance of SPECT imaging. / Schillaci, O.; Massa, R.; Scopinaro, F.
In: Journal of Nuclear Medicine, Vol. 41, No. 3, 2000, p. 459-462.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 111In-pentetreotide scintigraphy in the detection of insulinomas
T2 - Importance of SPECT imaging
AU - Schillaci, O.
AU - Massa, R.
AU - Scopinaro, F.
PY - 2000
Y1 - 2000
N2 - The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas. Methods: Fourteen patients were evaluated. After 111Inpentetreotide injection (~250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients. Results: SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings. Conclusion: SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.
AB - The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas. Methods: Fourteen patients were evaluated. After 111Inpentetreotide injection (~250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients. Results: SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings. Conclusion: SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.
KW - Insulinomas
KW - Somatostatin receptor scintigraphy
KW - SPECT
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UR - http://www.scopus.com/inward/citedby.url?scp=0033622158&partnerID=8YFLogxK
M3 - Article
C2 - 10716319
AN - SCOPUS:0033622158
VL - 41
SP - 459
EP - 462
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 3
ER -