111In-pentetreotide SPECT/CT in pulmonary carcinoid

Agostino Chiaravalloti, Angela Spanu, Roberta Danieli, Francesca Dore, Bastiana Piras, Antonio Falchi, Mario Tavolozza, Giuseppe Madeddu, Orazio Schillaci

Research output: Contribution to journalArticle

Abstract

Aim: We evaluated somatostatin receptor scintigraphy (SRS) with 111In-pentetreotide incremental value in pulmonary carcinoid (PC) diagnosis compared to contrast enhanced Computed Tomography (ceCT). Patients and Methods: We enrolled 81 patients with ascertained PC, 39 at initial staging and 42 in follow-up; the primary tumor had already been excised in 68 cases. Single Photon emission Computed Tomography (SPECT) images were reconstructed with the iterative method and fused with non-enhanced Computed tomography (CT) images. Results: Primary PC or metastatic lesions were ascertained in 55/81 patients and SPECT/CT was positive in 50/55 cases, while ceCT was positive in 44/55. Comparing SPECT/CT with ceCT results, we found a sensitivity of 96 vs. 87.5%, and specificity of 92% vs. 97% for the detection of primary lesion or recurrent disease. A total of 198 lesions were ascertained at SPECT/CT, while 161 at ceCT, with values of sensitivity and specificity of 85.5% and 84.6% for SRS and 75.2% and 90.5% respectively. Conclusion: 111In-Pentetreotide SPECT/CT proved to be more sensitive and accurate than ceCT, thus enhancing its role in evaluating patients with PC.

Original languageEnglish
Pages (from-to)4265-4270
Number of pages6
JournalAnticancer Research
Volume35
Issue number7
Publication statusPublished - Jul 1 2015

Keywords

  • <sup>111</sup>In-pentetreotide
  • NET
  • Pulmonary carcinoid
  • Scintigraphy
  • Somatostatin receptors
  • SPECT

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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  • Cite this

    Chiaravalloti, A., Spanu, A., Danieli, R., Dore, F., Piras, B., Falchi, A., Tavolozza, M., Madeddu, G., & Schillaci, O. (2015). 111In-pentetreotide SPECT/CT in pulmonary carcinoid. Anticancer Research, 35(7), 4265-4270.