Abstract
Objectives. The purpose of this multicentre study was to assess the accuracy and reproducibility of the 13C-octanoic acid breath test compared to scintigraphy for measurement of gastric emptying. Methods. Sixty-nine healthy subjects (40 men, 29 women; mean age 30 years, range 21-61) were studied at least once by using the 13C-octanoic breath test. In 34 healthy subjects, gastric emptying was simultaneously measured by gastric scintigraphy, and the 13C-octanoic breath test was then repeated in 18 of these cases. Fifty-four patients (30 men, 24 women; mean age 46 years, range 13-74) with dyspeptic or reflux symptoms were studied according to the same procedure. Results. The correlation between breath test and scintigraphic values was highly significant (r = 0.744, P <0.001). The concordance of results of scintigraphy and breath test (normal versus abnormal) and the reproducibility (Bland and Altman method) of the breath test were good (CVinter = 24, CVintra = 15). As compared to scintigraphy, breath test detected an abnormal gastric emptying with 67 sensitivity and 80 specificity (ROC analysis). Conclusion. These results confirm the value of breath test as an accurate measurement of gastric emptying. Its excellent reproducibility makes it a method of choice for pharmacological studies. However, at least when scintigraphy is considered the gold standard, breath test sensitivity may be insufficient for the detection of gastroparesis in an individual patient. (C) 2000 Lippincott Williams and Wilkins.
| Original language | English |
|---|---|
| Pages (from-to) | 85-91 |
| Number of pages | 7 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 12 |
| Issue number | 1 |
| Publication status | Published - 2000 |
Fingerprint
Keywords
- Breath test
- Gastric emptying
- Octanoic acid
- Scintigraphy
ASJC Scopus subject areas
- Gastroenterology
Cite this
13C-octanoic acid breath test for gastric emptying measurement. / Delbende, Bruno; Perri, Francesco; Couturier, Olivier; Leodolter, Andreas; Mauger, Pascale; Bridgi, Boumediene; Bizais, Yves; Bruley Des Varannes, Stanislas; Andriulli, Angelo; Galmiche, Jean Paul.
In: European Journal of Gastroenterology and Hepatology, Vol. 12, No. 1, 2000, p. 85-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 13C-octanoic acid breath test for gastric emptying measurement
AU - Delbende, Bruno
AU - Perri, Francesco
AU - Couturier, Olivier
AU - Leodolter, Andreas
AU - Mauger, Pascale
AU - Bridgi, Boumediene
AU - Bizais, Yves
AU - Bruley Des Varannes, Stanislas
AU - Andriulli, Angelo
AU - Galmiche, Jean Paul
PY - 2000
Y1 - 2000
N2 - Objectives. The purpose of this multicentre study was to assess the accuracy and reproducibility of the 13C-octanoic acid breath test compared to scintigraphy for measurement of gastric emptying. Methods. Sixty-nine healthy subjects (40 men, 29 women; mean age 30 years, range 21-61) were studied at least once by using the 13C-octanoic breath test. In 34 healthy subjects, gastric emptying was simultaneously measured by gastric scintigraphy, and the 13C-octanoic breath test was then repeated in 18 of these cases. Fifty-four patients (30 men, 24 women; mean age 46 years, range 13-74) with dyspeptic or reflux symptoms were studied according to the same procedure. Results. The correlation between breath test and scintigraphic values was highly significant (r = 0.744, P <0.001). The concordance of results of scintigraphy and breath test (normal versus abnormal) and the reproducibility (Bland and Altman method) of the breath test were good (CVinter = 24, CVintra = 15). As compared to scintigraphy, breath test detected an abnormal gastric emptying with 67 sensitivity and 80 specificity (ROC analysis). Conclusion. These results confirm the value of breath test as an accurate measurement of gastric emptying. Its excellent reproducibility makes it a method of choice for pharmacological studies. However, at least when scintigraphy is considered the gold standard, breath test sensitivity may be insufficient for the detection of gastroparesis in an individual patient. (C) 2000 Lippincott Williams and Wilkins.
AB - Objectives. The purpose of this multicentre study was to assess the accuracy and reproducibility of the 13C-octanoic acid breath test compared to scintigraphy for measurement of gastric emptying. Methods. Sixty-nine healthy subjects (40 men, 29 women; mean age 30 years, range 21-61) were studied at least once by using the 13C-octanoic breath test. In 34 healthy subjects, gastric emptying was simultaneously measured by gastric scintigraphy, and the 13C-octanoic breath test was then repeated in 18 of these cases. Fifty-four patients (30 men, 24 women; mean age 46 years, range 13-74) with dyspeptic or reflux symptoms were studied according to the same procedure. Results. The correlation between breath test and scintigraphic values was highly significant (r = 0.744, P <0.001). The concordance of results of scintigraphy and breath test (normal versus abnormal) and the reproducibility (Bland and Altman method) of the breath test were good (CVinter = 24, CVintra = 15). As compared to scintigraphy, breath test detected an abnormal gastric emptying with 67 sensitivity and 80 specificity (ROC analysis). Conclusion. These results confirm the value of breath test as an accurate measurement of gastric emptying. Its excellent reproducibility makes it a method of choice for pharmacological studies. However, at least when scintigraphy is considered the gold standard, breath test sensitivity may be insufficient for the detection of gastroparesis in an individual patient. (C) 2000 Lippincott Williams and Wilkins.
KW - Breath test
KW - Gastric emptying
KW - Octanoic acid
KW - Scintigraphy
UR - http://www.scopus.com/inward/record.url?scp=0033628623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033628623&partnerID=8YFLogxK
M3 - Article
C2 - 10656216
AN - SCOPUS:0033628623
VL - 12
SP - 85
EP - 91
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 1
ER -