13C-octanoic acid breath test for gastric emptying measurement

Bruno Delbende, Francesco Perri, Olivier Couturier, Andreas Leodolter, Pascale Mauger, Boumediene Bridgi, Yves Bizais, Stanislas Bruley Des Varannes, Angelo Andriulli, Jean Paul Galmiche

Research output: Contribution to journalArticle

Abstract

Objectives. The purpose of this multicentre study was to assess the accuracy and reproducibility of the 13C-octanoic acid breath test compared to scintigraphy for measurement of gastric emptying. Methods. Sixty-nine healthy subjects (40 men, 29 women; mean age 30 years, range 21-61) were studied at least once by using the 13C-octanoic breath test. In 34 healthy subjects, gastric emptying was simultaneously measured by gastric scintigraphy, and the 13C-octanoic breath test was then repeated in 18 of these cases. Fifty-four patients (30 men, 24 women; mean age 46 years, range 13-74) with dyspeptic or reflux symptoms were studied according to the same procedure. Results. The correlation between breath test and scintigraphic values was highly significant (r = 0.744, P <0.001). The concordance of results of scintigraphy and breath test (normal versus abnormal) and the reproducibility (Bland and Altman method) of the breath test were good (CVinter = 24, CVintra = 15). As compared to scintigraphy, breath test detected an abnormal gastric emptying with 67 sensitivity and 80 specificity (ROC analysis). Conclusion. These results confirm the value of breath test as an accurate measurement of gastric emptying. Its excellent reproducibility makes it a method of choice for pharmacological studies. However, at least when scintigraphy is considered the gold standard, breath test sensitivity may be insufficient for the detection of gastroparesis in an individual patient. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume12
Issue number1
Publication statusPublished - 2000

Keywords

  • Breath test
  • Gastric emptying
  • Octanoic acid
  • Scintigraphy

ASJC Scopus subject areas

  • Gastroenterology

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