18F-FDG PET/CT, 99mTc-MIBI, and MRI in the prediction of outcome of patients with multiple myeloma: A comparative study

Rosa Fonti, Leonardo Pace, Claudio Cerchione, Lucio Catalano, Barbara Salvatore, Serena De Luca, Fabrizio Pane, Marco Salvatore, Silvana Del Vecchio

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Purpose: The aim of this study was to compare the relative contribution of 18F-FDG PET/CT, 99mTc-MIBI, andMRI in predicting progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM) patients. Patients and Methods: Thirty-three newly diagnosed MM patients had been evaluated in a previous study by 18F-FDG PET/CT, 99mTc-MIBI, and spine and pelvis MRI reporting focal lesions and diffuse bone marrow involvement. Twenty-seven patients were then subjected to a mean follow-up period of 58 months, whereas 6 patients were lost. Results: 18F-FDG PET/CT, 99mTc-MIBI, and MRI were positive in 26, 24, and 22 patients, respectively, showing diffuse bone marrow involvement in 12, 21, and 17 patients and a total of 185, 56, and 39 focal lesions, respectively. At follow-up, 18 patients showed complete or partial remission, whereas 9 patients developed progressive disease, 7 of which died of myeloma. Univariate and subsequent multivariate analysis showed that 18F-FDG PET/CT focal uptake and 99mTc-MIBI focal and diffuse uptake predicted PFS (P = 0.0006), whereas 18F-FDG PET/CT focal uptake and 99mTc-MIBI focal uptake predicted OS (P = 0.0010). Although MRI diffuse pattern predicted PFS at univariate analysis (P = 0.0376), it was not retained in the model at multivariate analysis. Receiver operating characteristic curve analysis showed that the number of focal lesions best discriminating for PFS and OS prediction was 4 and 11 for 18F-FDG PET/CT and 2 in both cases for 99mTc-MIBI, respectively. By Kaplan-Meier analysis and log-rank testing, PFS and OS at follow-up were significantly better in patients showing a number of focal lesions at 18F-FDG PET/CT or 99mTc-MIBI lower than the respective cutoff (P = 0.03, P = 0.004, and P <0.0001, respectively). Finally, PFS was significantly better in patients showing absent/faint diffuse 99mTc-MIBI uptake than in those having moderate/intense diffuse uptake (P = 0.0012). Conclusions: 18F-FDG PET/CT and 99mTc-MIBI may be useful in predicting PFS and OS in myeloma patients.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalClinical Nuclear Medicine
Issue number4
Publication statusPublished - Apr 21 2015


  • Tc-MIBI
  • MRI
  • Multiple myeloma
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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