68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

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Abstract

Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

Original languageEnglish
Pages (from-to)E336-E338
JournalClinical Nuclear Medicine
Volume46
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • Ga-DOTATOC
  • pleural tumor
  • positron emission tomography
  • solitary fibrous tumor
  • somatostatin receptors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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