68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo; Vittoria Rufini; Angelina Filice; Massimiliano Paci; Guido Rindi

doi:10.1097/RLU.0000000000003570

⁶⁸Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo, Vittoria Rufini, Angelina Filice, Massimiliano Paci, Guido Rindi

Research output: Contribution to journal › Article › peer-review

Abstract

Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

Original language	English
Pages (from-to)	E336-E338
Journal	Clinical Nuclear Medicine
Volume	46
Issue number	6
DOIs	https://doi.org/10.1097/RLU.0000000000003570
Publication status	Published - Jun 2021

Keywords

Ga-DOTATOC
pleural tumor
positron emission tomography
solitary fibrous tumor
somatostatin receptors

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000003570

Cite this

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title = "68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors",

abstract = "Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.",

keywords = "Ga-DOTATOC, pleural tumor, positron emission tomography, solitary fibrous tumor, somatostatin receptors",

author = "Filippo Lococo and Vittoria Rufini and Angelina Filice and Massimiliano Paci and Guido Rindi",

year = "2021",

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T1 - 68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

AU - Lococo, Filippo

AU - Rufini, Vittoria

AU - Filice, Angelina

AU - Paci, Massimiliano

AU - Rindi, Guido

PY - 2021/6

Y1 - 2021/6

N2 - Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

AB - Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

KW - Ga-DOTATOC

KW - pleural tumor

KW - positron emission tomography

KW - solitary fibrous tumor

KW - somatostatin receptors

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