99mTc-sestamibi and 201-Thallium at rest: Dual scintigraphic mapping of myocardial injury in infarcted patients

R. Cassone, C. Moroni, O. Schillaci, C. Affricano, F. Scopinaro

Research output: Contribution to journalArticlepeer-review

Abstract

201-Thallium (Tl) and 99mTc-sestamibi (SM) present different biological properties and kinetics, suggesting a complementary evaluation of mitochondrial and cell membrane functions with subsequent implications regarding myocardial injury mapping. To verify the usefulness of a dual isotopic approach in Q infarcted patients, 30 subjects were submitted at rest, within 5 days, to SM imaging, 4 h-delayed Tl scans and echocardiography (ECHO). Left ventricle segmental uptake and wall motion were graded on a 3 points scale (0 = absent to 2 = normal) and compared on the basis of an 11 segments model. Results and discussion. 1) The analysis of SM normal segments demonstrated a strong concordance (97%) with Tl and ECHO, suggesting that both mitochondrial and cell membrane functions are preserved; 2) 49% of SM graded 0 segments were scored 1 by Tl and ECHO, suggesting a worse impairment of mitochondrial function with respect to cell membrane function; 3) ~ 55% of segments showing a reduced MIBI uptake were found normal using Tl, then an impaired mitochondrial but a normal cell membrane function could be hypothesized. 4) Tl provided a better estimation of the effective infarction size with respect to SM. Conclusions. The SM and Tl dual approach, allowing scintigraphic mapping of myocardial injury, seems to provide a useful tool for a complete evaluation of infarcted patients.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalJournal of Cardiovascular Surgery
Volume37
Issue number6
Publication statusPublished - 1996

Keywords

  • 201-Thallium
  • Tc-sestamibi
  • echocardiography
  • myocardial infarction
  • myocardial scintigraphy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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