Tomografia cardiaca con 99mTc tetrofosmina dopo somministrazione di nitrati in pazienti con cardiopatia ischemica e disfunzione ventricolare sinistra

Translated title of the contribution: 99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction

F. Menna, W. Acampa, L. Florimonte, A. Ferro, G. Borrelli, C. Mainolfi, A. Cuocolo

Research output: Contribution to journalArticle

Abstract

Purpose. To investigate the role of technetium-99m (99mTc) tetrofosmin single-photon emission Computed Tomography (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium in patients with chronic coronary artery disease and left ventricular (LV) dysfunction. Material and methods. Twenty-two patients (mean age 54±11 years) with coronary artery disease, previous myocardial infarction and LV dysfunction (LV ejection fraction 38±13%) were examined. On differente days all patients underwent 99mTc tetrofosmin (740 MBq) SPECT under control conditions at rest and after sublingual nitroglycerin administration (10 mg). Regional tetrofosmin activity was quantitatively measured in 22 myocardial segments per patient. In each segment, tracer uptake was expressed as a percentage of the region with the peak activity. Results. Under control conditions, 267 myocardial segments (55%) showed normal tetrofosmin uptake (>70% of peak activity), 107 segments (22%) showed a moderate reduction (51- 70%) and 110 segments (23%) a severe reduction (≤50%) in tracer uptake. Among the 110 segments with a severe reduction in tetrofosmin uptake 20 (18%) showed increased tracer uptake ≥10% of after nitrate administration (from 44±5% to 58±3%, p

Translated title of the contribution99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction
Original languageItalian
Pages (from-to)258-263
Number of pages6
JournalRadiologia Medica
Volume99
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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