Superficial Enhanced Fluid Fat Injection (SEFFI) to correct volume defects and skin aging of the face and periocular region

Francesco P. Bernardini, Alessandro Gennai, Luigi Izzo, Alessandra Zambelli, Erica Repaci, Ilaria Baldelli, G. Fraternali-Orcioni, Morris E. Hartstein, Pier Luigi Santi, Rodolfo Quarto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Although recent research on micro fat has shown the potential advantages of superficial implantation and high stem cell content, clinical applications thus far have been limited. Objectives The authors report their experience with superficial enhanced fluid fat injection (SEFFI) for the correction of volume loss and skin aging of the face in general and in the periocular region. Methods The finer SEFFI preparation (0.5 mL) was injected into the orbicularis in the periorbital and perioral areas, and the 0.8-mL preparation was injected subdermally elsewhere in the face. Results The records of 98 consecutive patients were reviewed. Average follow-up time was 6 months, and average volume of implanted fat was 20 mL and 51.4 mL for the 0.5-mL and 0.8-mL preparations, respectively. Good or excellent results were achieved for volume restoration and skin improvement in all patients. Complications were minor and included an oil cyst in 3 patients. The smaller SEFFI quantity (0.5 mL) was well suited to correct volume loss in the eyelids, especially the deep upper sulcus and tear trough, whereas the larger SEFFI content was effective for larger volume deficits in other areas of the face, including the brow, temporal fossa, zygomatic-malar region, nasolabial folds, marionette lines, chin, and lips. Conclusions The fat administered by SEFFI is easily harvested via small side-port cannulae, yielding micro fat that is rich in viable adipocytes and stem cells. Both volumes of fat (0.5 mL and 0.8 mL) were effective for treating age-related lipoatrophy, reducing facial rhytids, and improving skin quality.

Original languageEnglish
Pages (from-to)504-515
Number of pages12
JournalAesthetic Surgery Journal
Volume35
Issue number5
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Skin Aging
Fats
Injections
Stem Cells
Nasolabial Fold
Chin
Skin
Eyelids
Lip
Tears
Adipocytes
Cysts
Oils

Keywords

  • superficial fat implant

ASJC Scopus subject areas

  • Surgery

Cite this

Superficial Enhanced Fluid Fat Injection (SEFFI) to correct volume defects and skin aging of the face and periocular region. / Bernardini, Francesco P.; Gennai, Alessandro; Izzo, Luigi; Zambelli, Alessandra; Repaci, Erica; Baldelli, Ilaria; Fraternali-Orcioni, G.; Hartstein, Morris E.; Santi, Pier Luigi; Quarto, Rodolfo.

In: Aesthetic Surgery Journal, Vol. 35, No. 5, 01.07.2015, p. 504-515.

Research output: Contribution to journalArticle

Bernardini, FP, Gennai, A, Izzo, L, Zambelli, A, Repaci, E, Baldelli, I, Fraternali-Orcioni, G, Hartstein, ME, Santi, PL & Quarto, R 2015, 'Superficial Enhanced Fluid Fat Injection (SEFFI) to correct volume defects and skin aging of the face and periocular region', Aesthetic Surgery Journal, vol. 35, no. 5, pp. 504-515. https://doi.org/10.1093/asj/sjv001
Bernardini, Francesco P. ; Gennai, Alessandro ; Izzo, Luigi ; Zambelli, Alessandra ; Repaci, Erica ; Baldelli, Ilaria ; Fraternali-Orcioni, G. ; Hartstein, Morris E. ; Santi, Pier Luigi ; Quarto, Rodolfo. / Superficial Enhanced Fluid Fat Injection (SEFFI) to correct volume defects and skin aging of the face and periocular region. In: Aesthetic Surgery Journal. 2015 ; Vol. 35, No. 5. pp. 504-515.
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AU - Zambelli, Alessandra

AU - Repaci, Erica

AU - Baldelli, Ilaria

AU - Fraternali-Orcioni, G.

AU - Hartstein, Morris E.

AU - Santi, Pier Luigi

AU - Quarto, Rodolfo

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N2 - Background Although recent research on micro fat has shown the potential advantages of superficial implantation and high stem cell content, clinical applications thus far have been limited. Objectives The authors report their experience with superficial enhanced fluid fat injection (SEFFI) for the correction of volume loss and skin aging of the face in general and in the periocular region. Methods The finer SEFFI preparation (0.5 mL) was injected into the orbicularis in the periorbital and perioral areas, and the 0.8-mL preparation was injected subdermally elsewhere in the face. Results The records of 98 consecutive patients were reviewed. Average follow-up time was 6 months, and average volume of implanted fat was 20 mL and 51.4 mL for the 0.5-mL and 0.8-mL preparations, respectively. Good or excellent results were achieved for volume restoration and skin improvement in all patients. Complications were minor and included an oil cyst in 3 patients. The smaller SEFFI quantity (0.5 mL) was well suited to correct volume loss in the eyelids, especially the deep upper sulcus and tear trough, whereas the larger SEFFI content was effective for larger volume deficits in other areas of the face, including the brow, temporal fossa, zygomatic-malar region, nasolabial folds, marionette lines, chin, and lips. Conclusions The fat administered by SEFFI is easily harvested via small side-port cannulae, yielding micro fat that is rich in viable adipocytes and stem cells. Both volumes of fat (0.5 mL and 0.8 mL) were effective for treating age-related lipoatrophy, reducing facial rhytids, and improving skin quality.

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