Superimposed nephritis: A separate entity among glomerular diseases?

T. Bertani, G. Mecca, G. Sacchi, G. Remuzzi

Research output: Contribution to journalArticlepeer-review


The concomitant occurrence of two glomerular diseases in the same patient was diagnosed in seven out of 105 patients udergoing renal biopsy for suspected glomerulopathy. The most frequently associated disease was a membranous type glomerulopathy. The follow-up was characterized by a rapid deterioration of renal function and two patients were required to start a chronic hemodialysis program soon after the diagnosis. It is suggested that the observed coexisting patterns of glomerular injury do not occur on the basis of chance alone and should be considered as a separate entity in glomerular pathology. In all cases, clinical and pathologic findings were strongly suggestive for two consecutive distinct pathologic processes, thus justifying the use of the term superimposed nephritis. It is reasonable to assume that the mechanisms responsible for glomerular damage and for the evolution of the disease in superimposed nephritis are different from those regulating the corresponding glomerulonephritis when occurring alone. The high prevalence of membranous pattern in superimposed nephritis indicates that preexisting glomerular alterations might favor an immune reaction in the subepithelial space.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalAmerican Journal of Kidney Diseases
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Nephrology


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