Superoxide dismutase 1 modulates expression of transferrin receptor

Ruth Danzeisen, Tilmann Achsel, Ulrich Bederke, Mauro Cozzolino, Claudia Crosio, Alberto Ferri, Malte Frenzel, Edith Butler Gralla, Lea Huber, Albert Ludolph, Monica Nencini, Giuseppe Rotilio, Joan Selverstone Valentine, Maria Teresa Carrì

Research output: Contribution to journalArticle

Abstract

Copper-zinc superoxide dismutase (SOD1) plays a protective role against the toxicity of superoxide, and studies in Saccharomyces cerevisiae and in Drosophila have suggested an additional role for SOD1 in iron metabolism. We have studied the effect of the modulation of SOD1 levels on iron metabolism in a cultured human glial cell line and in a mouse motoneuronal cell line. We observed that levels of the transferrin receptor and the iron regulatory protein 1 were modulated in response to altered intracellular levels of superoxide dismutase activity, carried either by wild-type SOD1 or by an SOD-active amyotrophic lateral sclerosis (ALS) mutant enzyme, G93A-SOD1, but not by a superoxide dismutase inactive ALS mutant, H46R-SOD1. Ferritin expression was also increased by wild-type SOD1 overexpression, but not by mutant SOD1s. We propose that changes in superoxide levels due to alteration of SOD1 activity affect iron metabolism in glial and neuronal cells from higher eukaryotes and that this may be relevant to diseases of the nervous system.

Original languageEnglish
Pages (from-to)489-498
Number of pages10
JournalJournal of Biological Inorganic Chemistry
Volume11
Issue number4
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Ferritin
  • Iron metabolism
  • Iron regulatory protein
  • Oxidative stress
  • Superoxide dismutase
  • Transferrin receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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  • Cite this

    Danzeisen, R., Achsel, T., Bederke, U., Cozzolino, M., Crosio, C., Ferri, A., Frenzel, M., Gralla, E. B., Huber, L., Ludolph, A., Nencini, M., Rotilio, G., Valentine, J. S., & Carrì, M. T. (2006). Superoxide dismutase 1 modulates expression of transferrin receptor. Journal of Biological Inorganic Chemistry, 11(4), 489-498. https://doi.org/10.1007/s00775-006-0099-4