Superoxide dismutase and the reduction of reperfusion-induced arrhythmias: In vivo dose-response studies in the rat

Emma Riva, Allan S. Manning, David J. Hearse

Research output: Contribution to journalArticlepeer-review

Abstract

Using anesthetized rats we have investigated the dose-response characteristics for the ability of superoxide dismutase (SOD) to reduce the vulnerability of the rat heart to reperfusion-induced arrhythmias in vivo. Hearts (n=15 in each group) were subjected to 7 min of regional ischemia followed by 10 min of reperfusion. In the control group (saline), 73% (11/15) of the hearts fibrillated during reperfusion, 20% (3/15) had atrioventricular block and 47% (7/15) died as a result of ventricular arrhythmias. Superoxide dismutase, administered as an intravenous bolus 2 min prior to reperfusion exerted a marked protective effect. At its most effective dose (10 mg/kg body wt i.e. 27,000 IU/kg body wt) reperfusion-induced ventricular fibrillation was reduced to 33% (5/15). Reperfusion-induced atrioventricular block was eliminated (0/15) and mortality was reduced to 7% (1/15, p

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalCardiovascular Drugs and Therapy
Volume1
Issue number2
DOIs
Publication statusPublished - Aug 1987

Keywords

  • anti-arrhythmic agents
  • free radicals
  • rat heart
  • regional ischemia
  • reperfusion
  • superoxide
  • superoxide dismutase

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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