TY - JOUR
T1 - Superoxide dismutase, glutathione peroxidase and catalase in oxidative hemolysis. A study of Fanconi's anemia erythrocytes
AU - Mavelli, I.
AU - Ciriolo, M. R.
AU - Rotilio, G.
AU - De Sole, P.
AU - Castorino, M.
AU - Stabile, A.
PY - 1982/5/31
Y1 - 1982/5/31
N2 - Superoxide dismutase, glutathione peroxidase and catalase were assayed in the erythrocytes of three patients of Fanconi's anemia. Superoxide dismutase was found to be significantly decreased, as previously reported. The enzymes metabolizing H2O2 are normal (glutathione peroxidase in the higher limits of the normal value). The abnormal erythrocytes were found to be as resistant (perhaps more resistant) as normal red blood cells to oxidative hemolysis induced by drugs. Malonyl dialdehyde production was found to be comparable to that of normal erythrocytes. It is concluded that a significant (30-40%) deficiency of superoxide dismutase, when associated to normal values of H2O2-removing enzymes, does not affect the antioxidative defense capability of erythrocytes, even in conditions of augmented oxidative injury.
AB - Superoxide dismutase, glutathione peroxidase and catalase were assayed in the erythrocytes of three patients of Fanconi's anemia. Superoxide dismutase was found to be significantly decreased, as previously reported. The enzymes metabolizing H2O2 are normal (glutathione peroxidase in the higher limits of the normal value). The abnormal erythrocytes were found to be as resistant (perhaps more resistant) as normal red blood cells to oxidative hemolysis induced by drugs. Malonyl dialdehyde production was found to be comparable to that of normal erythrocytes. It is concluded that a significant (30-40%) deficiency of superoxide dismutase, when associated to normal values of H2O2-removing enzymes, does not affect the antioxidative defense capability of erythrocytes, even in conditions of augmented oxidative injury.
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U2 - 10.1016/0006-291X(82)91107-X
DO - 10.1016/0006-291X(82)91107-X
M3 - Article
C2 - 7103992
AN - SCOPUS:0020362126
VL - 106
SP - 286
EP - 290
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -