Superoxide dismutase in the nonobese diabetic (NOD) mouse: A dynamic time-course study

Gianpaolo Papaccio, Sonia Frascatore, Francesco Aurelio Pisanti, Michael V G Latronico, Thomas Linn

Research output: Contribution to journalArticlepeer-review

Abstract

Superoxide dismutase (SOD) levels, thought to be the first cellular defence against free radicals, were studied in the nonobese diabetesprone (NOD-p) mouse, an animal model of type 1 diabetes in which about 100% of females and 20% of males become diabetic. Nonobese diabetes non-prone (NON-p) mice were used as controls. Animals were followed from 5th to 22nd week of life. Results show that SOD levels in female NOD-p mice are extremely low. In males, values are considerably higher than in females but still lower than values found in control mice. Moreover, SOD levels did not significantly change with age, degree of insulitis or level of diabetes. Islet β cells in this strain, therefore, seem to be poorly protected against the negative effects of free radicals and this may predispose to diabetes. Furthermore, alterations of SOD may not be directly related to the development of the disease as the enzyme's activity is not further modified with age or the progression of diabetes.

Original languageEnglish
Pages (from-to)2223-2228
Number of pages6
JournalLife Sciences
Volume56
Issue number25
DOIs
Publication statusPublished - May 12 1995

Keywords

  • islet of Langerhans
  • nonobese diabetic mouse
  • Superoxide dismutase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

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