Superselective intra-arterial radiometabolic therapy with I-131 lipiodol in hepatocellular carcinoma

Carlo L. Maini, Maria G. Scelsa, Concetta Fiumara, Anna Tofani, Rosa Sciuto, Luigi Tipaldi, Marco D'Annibale, Eugenio Santoro

Research output: Contribution to journalArticle

Abstract

Superselective transcatheter arterial radioembolization with radioiodinated lipiodol and gelatin sponges was evaluated In 11 patients with nodular hepatocellular carcinoma. Thirteen tumor nodules were treated using 3-5 ml of lipiodol labeled with 259 to 2220 MBq of I-131 followed by gelatin sponge with the following results: 1) there was elevated uptake in 12 tumor nodules with high tumor-to-background ratios; 2) there was excellent clinical tolerance to the treatment (stable cirrhosis in 5 patients and cirrhosis progression in 2 cases); 3) there was good disease control with size reduction in five tumor lesions (41%) and no increase in seven lesions (59%) followed for 2 years; 4) there was a 2-year survival rate of 70%; and 5) three deaths due to hepatic failure at 2, 3, and 20 months after therapy. Superselective arterial radioembolization with I-131 lipiodol is a useful palliative approach to inoperable hepatocarcinoma, providing long-term local control without severe complications in the progression of cirrhosis.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalClinical Nuclear Medicine
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Maini, C. L., Scelsa, M. G., Fiumara, C., Tofani, A., Sciuto, R., Tipaldi, L., D'Annibale, M., & Santoro, E. (1996). Superselective intra-arterial radiometabolic therapy with I-131 lipiodol in hepatocellular carcinoma. Clinical Nuclear Medicine, 21(3), 221-226. https://doi.org/10.1097/00003072-199603000-00008