Identificazione automatica controllata di nuove lesioni in studi RM encefalici longitudinali di pazienti affetti da sclerosi multipla

Translated title of the contribution: Supervised automatic procedure to identify new lesions in brain MR longitudinal studies of patients with multiple sclerosis

R. C. Parodi, F. Levrero, M. P. Sormani, A. Pilot, G. L. Mancardi, A. Aliprandi, F. Sardanelli

Research output: Contribution to journalArticle

Abstract

Purpose. Identification of new enhancing lesions is a major endpoint of longitudinal brain magnetic resonance (MR) studies of multiple sclerosis (MS). To date, this is a visual, time-consuming procedure. We present here a supervised automated procedure (SAP) aimed at reducing the time needed to identify new MS enhancing lesions. Materials and methods. The SAP uses an algorithm including Cartesian coordinates of the lesions to be compared, their area and a constant (k). The procedure was validated for enhancing lesions on T1-weighted spin-echo images after intravenous administration of 0.1 mmol/kg of paramagnetic contrast agent, randomly selected from a dataset of a longitudinal MR study on ten relapsing-remitting MS patients followed for 2-5 years. During the validation session, two readers decided by consensus whether two lesions, present on the same slice of two examinations performed on subsequent dates, were the same or not. In this way, k was calibrated to obtain the same result from both visual inspection and automatic algorithm output. Results. After evaluating of 25±5 (mean±standard deviation) lesions in each of ten different sessions with correction of k value, the k value became a stable value (0.45±0.05). Conclusions. Once the suitable value of k was found, SAP was able to identify new enhancing lesions, avoiding visual inspection, which is usually a lengthy procedure.

Original languageItalian
Pages (from-to)300-306
Number of pages7
JournalRadiologia Medica
Volume113
Issue number2
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Multiple Sclerosis
Longitudinal Studies
Magnetic Resonance Spectroscopy
Brain
Relapsing-Remitting Multiple Sclerosis
Intravenous Administration
Contrast Media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Identificazione automatica controllata di nuove lesioni in studi RM encefalici longitudinali di pazienti affetti da sclerosi multipla. / Parodi, R. C.; Levrero, F.; Sormani, M. P.; Pilot, A.; Mancardi, G. L.; Aliprandi, A.; Sardanelli, F.

In: Radiologia Medica, Vol. 113, No. 2, 03.2008, p. 300-306.

Research output: Contribution to journalArticle

Parodi, R. C. ; Levrero, F. ; Sormani, M. P. ; Pilot, A. ; Mancardi, G. L. ; Aliprandi, A. ; Sardanelli, F. / Identificazione automatica controllata di nuove lesioni in studi RM encefalici longitudinali di pazienti affetti da sclerosi multipla. In: Radiologia Medica. 2008 ; Vol. 113, No. 2. pp. 300-306.
@article{2083dbe9306b49338bd7f6963eb6b4ad,
title = "Identificazione automatica controllata di nuove lesioni in studi RM encefalici longitudinali di pazienti affetti da sclerosi multipla",
abstract = "Purpose. Identification of new enhancing lesions is a major endpoint of longitudinal brain magnetic resonance (MR) studies of multiple sclerosis (MS). To date, this is a visual, time-consuming procedure. We present here a supervised automated procedure (SAP) aimed at reducing the time needed to identify new MS enhancing lesions. Materials and methods. The SAP uses an algorithm including Cartesian coordinates of the lesions to be compared, their area and a constant (k). The procedure was validated for enhancing lesions on T1-weighted spin-echo images after intravenous administration of 0.1 mmol/kg of paramagnetic contrast agent, randomly selected from a dataset of a longitudinal MR study on ten relapsing-remitting MS patients followed for 2-5 years. During the validation session, two readers decided by consensus whether two lesions, present on the same slice of two examinations performed on subsequent dates, were the same or not. In this way, k was calibrated to obtain the same result from both visual inspection and automatic algorithm output. Results. After evaluating of 25±5 (mean±standard deviation) lesions in each of ten different sessions with correction of k value, the k value became a stable value (0.45±0.05). Conclusions. Once the suitable value of k was found, SAP was able to identify new enhancing lesions, avoiding visual inspection, which is usually a lengthy procedure.",
keywords = "Magnetic resonance, Multiple sclerosis, New Gd-enhancing lesions",
author = "Parodi, {R. C.} and F. Levrero and Sormani, {M. P.} and A. Pilot and Mancardi, {G. L.} and A. Aliprandi and F. Sardanelli",
year = "2008",
month = "3",
doi = "10.1007/s11547-008-0251-z",
language = "Italian",
volume = "113",
pages = "300--306",
journal = "Radiologia Medica",
issn = "0033-8362",
publisher = "Springer-Verlag Italia s.r.l.",
number = "2",

}

TY - JOUR

T1 - Identificazione automatica controllata di nuove lesioni in studi RM encefalici longitudinali di pazienti affetti da sclerosi multipla

AU - Parodi, R. C.

AU - Levrero, F.

AU - Sormani, M. P.

AU - Pilot, A.

AU - Mancardi, G. L.

AU - Aliprandi, A.

AU - Sardanelli, F.

PY - 2008/3

Y1 - 2008/3

N2 - Purpose. Identification of new enhancing lesions is a major endpoint of longitudinal brain magnetic resonance (MR) studies of multiple sclerosis (MS). To date, this is a visual, time-consuming procedure. We present here a supervised automated procedure (SAP) aimed at reducing the time needed to identify new MS enhancing lesions. Materials and methods. The SAP uses an algorithm including Cartesian coordinates of the lesions to be compared, their area and a constant (k). The procedure was validated for enhancing lesions on T1-weighted spin-echo images after intravenous administration of 0.1 mmol/kg of paramagnetic contrast agent, randomly selected from a dataset of a longitudinal MR study on ten relapsing-remitting MS patients followed for 2-5 years. During the validation session, two readers decided by consensus whether two lesions, present on the same slice of two examinations performed on subsequent dates, were the same or not. In this way, k was calibrated to obtain the same result from both visual inspection and automatic algorithm output. Results. After evaluating of 25±5 (mean±standard deviation) lesions in each of ten different sessions with correction of k value, the k value became a stable value (0.45±0.05). Conclusions. Once the suitable value of k was found, SAP was able to identify new enhancing lesions, avoiding visual inspection, which is usually a lengthy procedure.

AB - Purpose. Identification of new enhancing lesions is a major endpoint of longitudinal brain magnetic resonance (MR) studies of multiple sclerosis (MS). To date, this is a visual, time-consuming procedure. We present here a supervised automated procedure (SAP) aimed at reducing the time needed to identify new MS enhancing lesions. Materials and methods. The SAP uses an algorithm including Cartesian coordinates of the lesions to be compared, their area and a constant (k). The procedure was validated for enhancing lesions on T1-weighted spin-echo images after intravenous administration of 0.1 mmol/kg of paramagnetic contrast agent, randomly selected from a dataset of a longitudinal MR study on ten relapsing-remitting MS patients followed for 2-5 years. During the validation session, two readers decided by consensus whether two lesions, present on the same slice of two examinations performed on subsequent dates, were the same or not. In this way, k was calibrated to obtain the same result from both visual inspection and automatic algorithm output. Results. After evaluating of 25±5 (mean±standard deviation) lesions in each of ten different sessions with correction of k value, the k value became a stable value (0.45±0.05). Conclusions. Once the suitable value of k was found, SAP was able to identify new enhancing lesions, avoiding visual inspection, which is usually a lengthy procedure.

KW - Magnetic resonance

KW - Multiple sclerosis

KW - New Gd-enhancing lesions

UR - http://www.scopus.com/inward/record.url?scp=43449091562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43449091562&partnerID=8YFLogxK

U2 - 10.1007/s11547-008-0251-z

DO - 10.1007/s11547-008-0251-z

M3 - Articolo

C2 - 18386130

AN - SCOPUS:43449091562

VL - 113

SP - 300

EP - 306

JO - Radiologia Medica

JF - Radiologia Medica

SN - 0033-8362

IS - 2

ER -