Abstract
Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P
| Original language | English |
|---|---|
| Pages (from-to) | 99-113 |
| Number of pages | 15 |
| Journal | Nutrition in Clinical Practice |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- amino acids, essential
- brain injuries
- infection
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury. / Boselli, Mirella; Aquilani, Roberto; Baiardi, Paola; Dioguardi, Francesco Saverio; Guarnaschelli, Caterina; Achilli, Maria Pia; Arrigoni, Nadia; Iadarola, Paolo; Verri, Manuela; Viglio, Simona; Barbieri, Annalisa; Boschi, Federica.
In: Nutrition in Clinical Practice, Vol. 27, No. 1, 02.2012, p. 99-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury
AU - Boselli, Mirella
AU - Aquilani, Roberto
AU - Baiardi, Paola
AU - Dioguardi, Francesco Saverio
AU - Guarnaschelli, Caterina
AU - Achilli, Maria Pia
AU - Arrigoni, Nadia
AU - Iadarola, Paolo
AU - Verri, Manuela
AU - Viglio, Simona
AU - Barbieri, Annalisa
AU - Boschi, Federica
PY - 2012/2
Y1 - 2012/2
N2 - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P
AB - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P
KW - amino acids, essential
KW - brain injuries
KW - infection
UR - http://www.scopus.com/inward/record.url?scp=84856757143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856757143&partnerID=8YFLogxK
U2 - 10.1177/0884533611431068
DO - 10.1177/0884533611431068
M3 - Article
C2 - 22307494
AN - SCOPUS:84856757143
VL - 27
SP - 99
EP - 113
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
SN - 0884-5336
IS - 1
ER -