Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury

Mirella Boselli, Roberto Aquilani, Paola Baiardi, Francesco Saverio Dioguardi, Caterina Guarnaschelli, Maria Pia Achilli, Nadia Arrigoni, Paolo Iadarola, Manuela Verri, Simona Viglio, Annalisa Barbieri, Federica Boschi

Research output: Contribution to journalArticle

Abstract

Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalNutrition in Clinical Practice
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • amino acids, essential
  • brain injuries
  • infection

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Boselli, M., Aquilani, R., Baiardi, P., Dioguardi, F. S., Guarnaschelli, C., Achilli, M. P., Arrigoni, N., Iadarola, P., Verri, M., Viglio, S., Barbieri, A., & Boschi, F. (2012). Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury. Nutrition in Clinical Practice, 27(1), 99-113. https://doi.org/10.1177/0884533611431068