TY - JOUR
T1 - Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury
AU - Boselli, Mirella
AU - Aquilani, Roberto
AU - Baiardi, Paola
AU - Dioguardi, Francesco Saverio
AU - Guarnaschelli, Caterina
AU - Achilli, Maria Pia
AU - Arrigoni, Nadia
AU - Iadarola, Paolo
AU - Verri, Manuela
AU - Viglio, Simona
AU - Barbieri, Annalisa
AU - Boschi, Federica
PY - 2012/2
Y1 - 2012/2
N2 - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P
AB - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P
KW - amino acids, essential
KW - brain injuries
KW - infection
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U2 - 10.1177/0884533611431068
DO - 10.1177/0884533611431068
M3 - Article
C2 - 22307494
AN - SCOPUS:84856757143
VL - 27
SP - 99
EP - 113
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
SN - 0884-5336
IS - 1
ER -