Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury

Mirella Boselli, Roberto Aquilani, Paola Baiardi, Francesco Saverio Dioguardi, Caterina Guarnaschelli, Maria Pia Achilli, Nadia Arrigoni, Paolo Iadarola, Manuela Verri, Simona Viglio, Annalisa Barbieri, Federica Boschi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalNutrition in Clinical Practice
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Essential Amino Acids
Brain Injuries
Rehabilitation
Infection
Traumatic Subarachnoid Hemorrhage
Stroke
Placebos
Prealbumin
Coma
Cross Infection
Odds Ratio
Confidence Intervals
Wounds and Injuries
Population

Keywords

  • amino acids, essential
  • brain injuries
  • infection

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury. / Boselli, Mirella; Aquilani, Roberto; Baiardi, Paola; Dioguardi, Francesco Saverio; Guarnaschelli, Caterina; Achilli, Maria Pia; Arrigoni, Nadia; Iadarola, Paolo; Verri, Manuela; Viglio, Simona; Barbieri, Annalisa; Boschi, Federica.

In: Nutrition in Clinical Practice, Vol. 27, No. 1, 02.2012, p. 99-113.

Research output: Contribution to journalArticle

Boselli, M, Aquilani, R, Baiardi, P, Dioguardi, FS, Guarnaschelli, C, Achilli, MP, Arrigoni, N, Iadarola, P, Verri, M, Viglio, S, Barbieri, A & Boschi, F 2012, 'Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury', Nutrition in Clinical Practice, vol. 27, no. 1, pp. 99-113. https://doi.org/10.1177/0884533611431068
Boselli, Mirella ; Aquilani, Roberto ; Baiardi, Paola ; Dioguardi, Francesco Saverio ; Guarnaschelli, Caterina ; Achilli, Maria Pia ; Arrigoni, Nadia ; Iadarola, Paolo ; Verri, Manuela ; Viglio, Simona ; Barbieri, Annalisa ; Boschi, Federica. / Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury. In: Nutrition in Clinical Practice. 2012 ; Vol. 27, No. 1. pp. 99-113.
@article{3250a24fb22d4d7aabadb020605f2810,
title = "Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury",
abstract = "Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8{\%}), subarachnoid hemorrhage (17.6{\%}), traumatic BI (7.2{\%}), and anoxic BI (6.4{\%}) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48{\%}); however, the rate was 23.2{\%} lower in the EAA group (23 episodes/63 patients; 36.5{\%}) than in the placebo group (37 episodes/62 patients; 59.7{\%}) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P",
keywords = "amino acids, essential, brain injuries, infection",
author = "Mirella Boselli and Roberto Aquilani and Paola Baiardi and Dioguardi, {Francesco Saverio} and Caterina Guarnaschelli and Achilli, {Maria Pia} and Nadia Arrigoni and Paolo Iadarola and Manuela Verri and Simona Viglio and Annalisa Barbieri and Federica Boschi",
year = "2012",
month = "2",
doi = "10.1177/0884533611431068",
language = "English",
volume = "27",
pages = "99--113",
journal = "Nutrition in Clinical Practice",
issn = "0884-5336",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury

AU - Boselli, Mirella

AU - Aquilani, Roberto

AU - Baiardi, Paola

AU - Dioguardi, Francesco Saverio

AU - Guarnaschelli, Caterina

AU - Achilli, Maria Pia

AU - Arrigoni, Nadia

AU - Iadarola, Paolo

AU - Verri, Manuela

AU - Viglio, Simona

AU - Barbieri, Annalisa

AU - Boschi, Federica

PY - 2012/2

Y1 - 2012/2

N2 - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P

AB - Background: To investigate whether supplementation with oral essential amino acids (EAAs) may reduce the occurrence of nosocomial infection among patients with brain injury (BI: stroke, trauma, anoxic coma). Methods: Patients (n = 125; 77 men, 48 women; mean age 63 ± 15 years) with stroke (68.8%), subarachnoid hemorrhage (17.6%), traumatic BI (7.2%), and anoxic BI (6.4%) 88 ± 15days after the index event. Patients were randomly assigned to 2 months of oral EAAs (n = 63; 8 g/d) or placebo (n = 62). Results: Over the first month of rehabilitation, there were 60 infections in the whole population of 125 patients (48%); however, the rate was 23.2% lower in the EAA group (23 episodes/63 patients; 36.5%) than in the placebo group (37 episodes/62 patients; 59.7%) (P 0.3 mg/dL were the best predictors of future infection (prealbumin: odds ratio [OR] = 4.17, confidence interval [CI] 1.84-9.45, P

KW - amino acids, essential

KW - brain injuries

KW - infection

UR - http://www.scopus.com/inward/record.url?scp=84856757143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856757143&partnerID=8YFLogxK

U2 - 10.1177/0884533611431068

DO - 10.1177/0884533611431068

M3 - Article

C2 - 22307494

AN - SCOPUS:84856757143

VL - 27

SP - 99

EP - 113

JO - Nutrition in Clinical Practice

JF - Nutrition in Clinical Practice

SN - 0884-5336

IS - 1

ER -