Support vector machine based on microRNA expression profiles to predict histological origin of ampullary carcinoma case report of a patient affected from adenocarcinoma of the papilla of vater with lynch syndrome

Francesca Tavano, Massimiliano Copetti, Ada Piepoli, Massimo Carella, Annamaria Gentile, Francesca Paola Burbaci, Andrea Fontana, Antonio De Bonis, Fabio Francesco Di Mola, Pierluigi Di Sebastiano, Angelo Andriulli

Research output: Contribution to journalArticle

Abstract

Adenocarcinomas of Vater's papilla (PVAC) may originate fromeither the pancreatic duct or the intestinal epithelium. Conflicting data have been reported about the frequency of the 2 anatomical entities and their influence on patients' prognosis. To ascertain the anatomical origin of PVAC in a family member of a Lynch syndrome kindred, we searched for microRNA (miRNA) expression profiles on resected tumor specimens. The support vector machine was trained on our previous miRNAs expression data sets of pancreatic and colorectal tissue samples and used to classify the site of origin of the tumor in our patient. The support vector machine worked by contrasting the profiles of miRNAs in patients with pancreatic ductal and colorectal cancers to that of our patient, which was finally classified as pancreatic ductal adenocarcinoma accordingly to alterations of 55 miRNAs. The PVAC might be originated from ductal epithelium rather than from the intestinal mucosa of the papilla in the case at issue. Alteration of miR-548b-3p, miR-551a, miR-21, miR-92a, miR-let-7i, and miR-181a∗ emerged as potentially associated with cancer genetic susceptibility in PVAC.

Original languageEnglish
Pages (from-to)626-629
Number of pages4
JournalPancreas
Volume45
Issue number4
DOIs
Publication statusPublished - Mar 4 2016

Keywords

  • Adenocarcinoma of the ampulla of Vater
  • MicroRNA
  • Support vector machine

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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