Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer

A. Santoni, C. Riccardi, T. Barlozzari, R. B. Heberman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalInternational Journal of Cancer
Volume26
Issue number6
Publication statusPublished - 1980

Fingerprint

Pyran Copolymer
Natural Killer Cells
Macrophages
Spleen
Thy-1 Antigens
Pyrans
Plastics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer. / Santoni, A.; Riccardi, C.; Barlozzari, T.; Heberman, R. B.

In: International Journal of Cancer, Vol. 26, No. 6, 1980, p. 837-843.

Research output: Contribution to journalArticle

Santoni, A. ; Riccardi, C. ; Barlozzari, T. ; Heberman, R. B. / Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer. In: International Journal of Cancer. 1980 ; Vol. 26, No. 6. pp. 837-843.
@article{ede3b55643a24ae3be3ce52dbfc7c55a,
title = "Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer",
abstract = "Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.",
author = "A. Santoni and C. Riccardi and T. Barlozzari and Heberman, {R. B.}",
year = "1980",
language = "English",
volume = "26",
pages = "837--843",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer

AU - Santoni, A.

AU - Riccardi, C.

AU - Barlozzari, T.

AU - Heberman, R. B.

PY - 1980

Y1 - 1980

N2 - Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.

AB - Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.

UR - http://www.scopus.com/inward/record.url?scp=0019135575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019135575&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 837

EP - 843

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 6

ER -