Abstract
Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.
| Original language | English |
|---|---|
| Pages (from-to) | 837-843 |
| Number of pages | 7 |
| Journal | International Journal of Cancer |
| Volume | 26 |
| Issue number | 6 |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer. / Santoni, A.; Riccardi, C.; Barlozzari, T.; Heberman, R. B.
In: International Journal of Cancer, Vol. 26, No. 6, 1980, p. 837-843.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer
AU - Santoni, A.
AU - Riccardi, C.
AU - Barlozzari, T.
AU - Heberman, R. B.
PY - 1980
Y1 - 1980
N2 - Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.
AB - Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019135575&partnerID=8YFLogxK
M3 - Article
VL - 26
SP - 837
EP - 843
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 6
ER -