Suppression of electrographic seizures is associated with amelioration of qtc interval prolongation in patients with traumatic brain injury

Wojciech Dabrowski, Dorota Siwicka-Gieroba, Todd T. Schlegel, Chiara Robba, Sami Zaid, Magdalena Bielacz, Andrzej Jaroszyński, Rafael Badenes

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relationship between ESz and possible changes in QTc interval and spatial QRS-T angle both during ESz and after ESz resolution. Methods: Adult patients with TBI were studied. Surface 12-lead ECGs were recorded using a Cardiax device during ESz events and 15 min after their effective suppression using barbiturate infusion. The ESz events were diagnosed using Masimo Root or bispectral index (BIS) devices. Results: Of the 348 patients considered for possible inclusion, ESz were noted in 72, with ECG being recorded in 21. Prolonged QTc was noted during ESz but significantly ameliorated after ESz suppression (540.19 ± 60.68 ms vs. 478.67 ± 38.52 ms, p < 0.001). The spatial QRS-T angle was comparable during ESz and after treatment. Regional cerebral oximetry increased following ESz suppression (from 58.4% ± 6.2 to 60.5% ± 4.2 (p < 0.01) and from 58.2% ± 7.2 to 60.8% ± 4.8 (p < 0.05) in the left and right hemispheres, respectively). Conclusion: QTc interval prolongation occurs during ESz events in TBI patients but both it and regional cerebral oximetry are improved after suppression of seizures.

Original languageEnglish
Article number5374
JournalJournal of Clinical Medicine
Volume10
Issue number22
DOIs
Publication statusPublished - Nov 1 2021

Keywords

  • Brain–heart interaction
  • QTc interval
  • Seizure
  • Spatial QTS-T angle
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

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