The effects of different levels of zinc (Zn) in the diet were tested in the animal model of acute experimental allergic encephalomyelitis (EAE), which is considered a prototype for cell-mediated autoimmune disease of the central nervous system (CNS). Acute EAE was induced in guinea pigs maintained with normal, high and low levels of Zn in the diet. The animals fed normal and Zn-supplemented diets showed the same survival rates; the incidence and severity of the disease was similar for both groups. Zn-deficient animals exhibited the expected symptoms of Zn deficiency and after sensitization did not develop neurological signs of EAE; some of them presented only focal inflammatory alteration in CNS.
- experimental allergic encephalomyelitis
- Guinea pigs
- Zinc deficiency
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics