Suppression of pentobarbitone-induced hyperactivity by past experience in mice

M. Sansone, F. Pavone, M. Battaglia, J. Vetulani

Research output: Contribution to journalArticlepeer-review


Locomotor activity of CD-1 mice, tested in an unfamiliar environment (toggle-floor box), was increased either by a subhypnotic dose (20 mg kg-1) of pentobarbitone or after recovery from pentobarbitone-induced (50 mg kg-1) anaesthesia. On the contrary, when mice were tested 6 h after a single exposure to the apparatus, pentobarbitone in either case failed to produce hyperactivity. The results demonstrate that mice recovering from barbiturate anaesthesia maintain susceptibility to the exteroceptive stimuli provided by a novel environment and knowledge of the environment acquired during past experience.

Original languageEnglish
Pages (from-to)784-785
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Issue number11
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology


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