Abstract
Locomotor activity of CD-1 mice, tested in an unfamiliar environment (toggle-floor box), was increased either by a subhypnotic dose (20 mg kg-1) of pentobarbitone or after recovery from pentobarbitone-induced (50 mg kg-1) anaesthesia. On the contrary, when mice were tested 6 h after a single exposure to the apparatus, pentobarbitone in either case failed to produce hyperactivity. The results demonstrate that mice recovering from barbiturate anaesthesia maintain susceptibility to the exteroceptive stimuli provided by a novel environment and knowledge of the environment acquired during past experience.
| Original language | English |
|---|---|
| Pages (from-to) | 784-785 |
| Number of pages | 2 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 41 |
| Issue number | 11 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Suppression of pentobarbitone-induced hyperactivity by past experience in mice. / Sansone, M.; Pavone, F.; Battaglia, M.; Vetulani, J.
In: Journal of Pharmacy and Pharmacology, Vol. 41, No. 11, 1989, p. 784-785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of pentobarbitone-induced hyperactivity by past experience in mice
AU - Sansone, M.
AU - Pavone, F.
AU - Battaglia, M.
AU - Vetulani, J.
PY - 1989
Y1 - 1989
N2 - Locomotor activity of CD-1 mice, tested in an unfamiliar environment (toggle-floor box), was increased either by a subhypnotic dose (20 mg kg-1) of pentobarbitone or after recovery from pentobarbitone-induced (50 mg kg-1) anaesthesia. On the contrary, when mice were tested 6 h after a single exposure to the apparatus, pentobarbitone in either case failed to produce hyperactivity. The results demonstrate that mice recovering from barbiturate anaesthesia maintain susceptibility to the exteroceptive stimuli provided by a novel environment and knowledge of the environment acquired during past experience.
AB - Locomotor activity of CD-1 mice, tested in an unfamiliar environment (toggle-floor box), was increased either by a subhypnotic dose (20 mg kg-1) of pentobarbitone or after recovery from pentobarbitone-induced (50 mg kg-1) anaesthesia. On the contrary, when mice were tested 6 h after a single exposure to the apparatus, pentobarbitone in either case failed to produce hyperactivity. The results demonstrate that mice recovering from barbiturate anaesthesia maintain susceptibility to the exteroceptive stimuli provided by a novel environment and knowledge of the environment acquired during past experience.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024841668&partnerID=8YFLogxK
M3 - Article
C2 - 2576049
AN - SCOPUS:0024841668
VL - 41
SP - 784
EP - 785
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 11
ER -