Abstract
Locomotor activity of CD-1 mice, tested in an unfamiliar environment (toggle-floor box), was increased either by a subhypnotic dose (20 mg kg-1) of pentobarbitone or after recovery from pentobarbitone-induced (50 mg kg-1) anaesthesia. On the contrary, when mice were tested 6 h after a single exposure to the apparatus, pentobarbitone in either case failed to produce hyperactivity. The results demonstrate that mice recovering from barbiturate anaesthesia maintain susceptibility to the exteroceptive stimuli provided by a novel environment and knowledge of the environment acquired during past experience.
Original language | English |
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Pages (from-to) | 784-785 |
Number of pages | 2 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 41 |
Issue number | 11 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology