Suppression of PHA-induced human T-lymphocyte colony formation following in vivo administration of anti-lymphocyte globulin - Report of one case

R. Ghio, V. Pistoia, Angela Perata, A. M. Marmont

Research output: Contribution to journalArticlepeer-review

Abstract

The administration of anti-lymphocyte globulin in a patient with pure red cell aplasia completely abrogated the PHA-induced T colony forming capacity of peripheral blood mononuclear cells. The possible mechanisms of the ALG-induced suppression are discussed. It is proposed that T-colony assays may represent an useful tool for monitoring some effects of immunosuppressive drugs on T cells.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalBlut
Volume47
Issue number6
DOIs
Publication statusPublished - 1983

Keywords

  • Anti-lymphocyte globulin
  • T-lymphocyte colonies

ASJC Scopus subject areas

  • Hematology

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