Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cells bearing Fc receptors (T(G)) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of unfractionated T cells (thus including T(G) cells) and T cells depleted of T(G), a sharp suppression of colony formation occurred when positively selected T(G) cells were readded to T(G)-depleted suspensions. Therefore, T(G) suppressor activity seems to be strictly dependent upon cell interaction with ox IgG immune complexes used for T(G) cell isolation. Different experimental approaches failed to demonstrate, although did not exclude, that suppression in this system is mediated by soluble factors. γ-irradiation of T(G) cells abrogated their suppressor capacity.
|Number of pages||5|
|Journal||Scandinavian Journal of Immunology|
|Publication status||Published - 1980|
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