Suppressor activity of T cells bearing Fc receptors for IgG on lymphoid colony formation

G. W. Canonica, V. Pistoia, R. Ghio, M. C. Mingari, L. Moretta

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Abstract

Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cells bearing Fc receptors (T(G)) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of unfractionated T cells (thus including T(G) cells) and T cells depleted of T(G), a sharp suppression of colony formation occurred when positively selected T(G) cells were readded to T(G)-depleted suspensions. Therefore, T(G) suppressor activity seems to be strictly dependent upon cell interaction with ox IgG immune complexes used for T(G) cell isolation. Different experimental approaches failed to demonstrate, although did not exclude, that suppression in this system is mediated by soluble factors. γ-irradiation of T(G) cells abrogated their suppressor capacity.

Original languageEnglish
Pages (from-to)507-511
Number of pages5
JournalScandinavian Journal of Immunology
Volume12
Issue number6
Publication statusPublished - 1980

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ASJC Scopus subject areas

  • Immunology

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