Supratentorial and infratentorial damage in spinocerebellar ataxia 2: A diffusion-weighted MRI study

Elena Salvatore, Enrico Tedeschi, Carmine Mollica, Caterina Vicidomini, Andrea Varrone, Anna Rita Daniela Coda, Arturo Brunetti, Marco Salvatore, Giuseppe De Michele, Alessandro Filla, Sabina Pappatà

Research output: Contribution to journalArticlepeer-review


Spinocerebellar ataxia type 2 (SCA2) is an autosomal-dominant degenerative disorder that is neuropathologically characterized primarily by infratentorial damage, although less severe supratentorial involvement may contribute to the clinical manifestation. Diffusion-weighted imaging (DWI)-Magnetic Resonance Imaging (MRI) studies of SCA2 have enabled in vivo quantification of neurodegeneration in infratentorial regions, whereas supratentorial regions have been explored less thoroughly. We measured microstructural changes in both infratentorial and supratentorial regions in 13 SCA2 patients (9 men, 4 women; mean age, 50±12 years) and 15 controls (10 men, 5 women; mean age, 49±14 years) using DWI-MRI and correlated the DWI changes with disease severity and duration. Disease severity was evaluated using the International Cooperative Ataxia Rating Scale and the Inherited Ataxia Clinical Rating Scale. Cerebral diffusion trace ( D-) values were generated, and regions of interest (ROIs) and voxel-based analysis with Statistical Parametric Mapping (SPM) were used for data analysis. In SCA2 patients, ROI analysis and SPM confirmed significant increases in D- values in the pons, cerebellar white matter (CWM) and middle cerebellar peduncles. Moreover, SPM analysis revealed increased D- values in the right thalamus, bilateral temporal cortex/white matter, and motor cortex/pyramidal tract regions. Increased diffusivity in the frontal white matter (FWM) and the CWM was significantly correlated with ataxia severity. DWI-MRI revealed that both infratentorial and supratentorial microstructural changes may characterize SCA2 patients in the course of the disease and might contribute to the severity of the symptoms.

Original languageEnglish
Pages (from-to)780-786
Number of pages7
JournalMovement Disorders
Issue number6
Publication statusPublished - 2014


  • Diffusion-weighted imaging
  • MRI
  • Neurodegeneration
  • SCA2
  • Spinocerebellar ataxia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)


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