Abstract
Objective: From January 1998 to February 1999, 160 patients undergoing lung resection for non-small cell lung cancer were studied to define factors that increase the risk of postoperative supraventricular arrhythmia (SA) and to assess the effectiveness of amiodarone as an antiarrhythmic drug. Methods: All patients were monitored intraoperatively and postoperatively up to day 3. Onset of SA was documented with ECG. Amiodarone was administered to those who developed SA with a loading dose of 5 mg/kg in 30 min and a maintenance dose of 15 mg/kg in 24 h. Results: Mean age was 64 years (range 27-83 years). There were nine wedge resections, six segmentectomies, 127 lobectomies and 18 pneumonectomies. Twenty-two patients (13%) had SA, all of which were atrial fibrillations. The incidence of supraventricular arrhythmia with pneumonectomy and lobectomy was 33 and 12%, respectively (P = 0.02). None of the patients who had a minor resection developed SA. The peak incidence of onset of SA occurred on postoperative day 2 and lasted from 1 to 12 days (average 3.4 days). Sinus rhythm was achieved with amiodarone in 20 patients (90.9%) with no side effects. Two patients received electrical cardioversion because hemodynamically unstable. Mean preoperative pO2 and pCO2 were lower in patients with SA: pO2 80.8 vs. 85 mmHg (P = 0.04); pCO2 35.5 vs. 38 mmHg (P=0.01). Patients with concomitant cardiopulmonary diseases presented an odds ratio for postoperative arrhythmia of 12.4 (confidence interval 4.5- 34.1) (P <0.0001). Conclusion: Concomitant cardiopulmonary diseases, lower pO2, pCO2 and extent of surgery increase the risk of postoperative SA after lung resection for non-small cell lung cancer. Cardiac monitoring in patients at risk is recommended. Amiodarone was both safe and effective in establishing and maintaining sinus rhythm. (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 12-16 |
| Number of pages | 5 |
| Journal | European Journal of Cardio-thoracic Surgery |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 2000 |
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Keywords
- Amiodarone
- Lung cancer
- Supraventricular arrhythmia
- Thoracotomy
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Supraventricular arrhythmia following lung resection for non-small cell lung cancer and its treatment with amiodarone. / Ciriaco, Paola; Mazzone, Patrizio; Canneto, Barbara; Zannini, Piero.
In: European Journal of Cardio-thoracic Surgery, Vol. 18, No. 1, 01.07.2000, p. 12-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Supraventricular arrhythmia following lung resection for non-small cell lung cancer and its treatment with amiodarone
AU - Ciriaco, Paola
AU - Mazzone, Patrizio
AU - Canneto, Barbara
AU - Zannini, Piero
PY - 2000/7/1
Y1 - 2000/7/1
N2 - Objective: From January 1998 to February 1999, 160 patients undergoing lung resection for non-small cell lung cancer were studied to define factors that increase the risk of postoperative supraventricular arrhythmia (SA) and to assess the effectiveness of amiodarone as an antiarrhythmic drug. Methods: All patients were monitored intraoperatively and postoperatively up to day 3. Onset of SA was documented with ECG. Amiodarone was administered to those who developed SA with a loading dose of 5 mg/kg in 30 min and a maintenance dose of 15 mg/kg in 24 h. Results: Mean age was 64 years (range 27-83 years). There were nine wedge resections, six segmentectomies, 127 lobectomies and 18 pneumonectomies. Twenty-two patients (13%) had SA, all of which were atrial fibrillations. The incidence of supraventricular arrhythmia with pneumonectomy and lobectomy was 33 and 12%, respectively (P = 0.02). None of the patients who had a minor resection developed SA. The peak incidence of onset of SA occurred on postoperative day 2 and lasted from 1 to 12 days (average 3.4 days). Sinus rhythm was achieved with amiodarone in 20 patients (90.9%) with no side effects. Two patients received electrical cardioversion because hemodynamically unstable. Mean preoperative pO2 and pCO2 were lower in patients with SA: pO2 80.8 vs. 85 mmHg (P = 0.04); pCO2 35.5 vs. 38 mmHg (P=0.01). Patients with concomitant cardiopulmonary diseases presented an odds ratio for postoperative arrhythmia of 12.4 (confidence interval 4.5- 34.1) (P <0.0001). Conclusion: Concomitant cardiopulmonary diseases, lower pO2, pCO2 and extent of surgery increase the risk of postoperative SA after lung resection for non-small cell lung cancer. Cardiac monitoring in patients at risk is recommended. Amiodarone was both safe and effective in establishing and maintaining sinus rhythm. (C) 2000 Elsevier Science B.V.
AB - Objective: From January 1998 to February 1999, 160 patients undergoing lung resection for non-small cell lung cancer were studied to define factors that increase the risk of postoperative supraventricular arrhythmia (SA) and to assess the effectiveness of amiodarone as an antiarrhythmic drug. Methods: All patients were monitored intraoperatively and postoperatively up to day 3. Onset of SA was documented with ECG. Amiodarone was administered to those who developed SA with a loading dose of 5 mg/kg in 30 min and a maintenance dose of 15 mg/kg in 24 h. Results: Mean age was 64 years (range 27-83 years). There were nine wedge resections, six segmentectomies, 127 lobectomies and 18 pneumonectomies. Twenty-two patients (13%) had SA, all of which were atrial fibrillations. The incidence of supraventricular arrhythmia with pneumonectomy and lobectomy was 33 and 12%, respectively (P = 0.02). None of the patients who had a minor resection developed SA. The peak incidence of onset of SA occurred on postoperative day 2 and lasted from 1 to 12 days (average 3.4 days). Sinus rhythm was achieved with amiodarone in 20 patients (90.9%) with no side effects. Two patients received electrical cardioversion because hemodynamically unstable. Mean preoperative pO2 and pCO2 were lower in patients with SA: pO2 80.8 vs. 85 mmHg (P = 0.04); pCO2 35.5 vs. 38 mmHg (P=0.01). Patients with concomitant cardiopulmonary diseases presented an odds ratio for postoperative arrhythmia of 12.4 (confidence interval 4.5- 34.1) (P <0.0001). Conclusion: Concomitant cardiopulmonary diseases, lower pO2, pCO2 and extent of surgery increase the risk of postoperative SA after lung resection for non-small cell lung cancer. Cardiac monitoring in patients at risk is recommended. Amiodarone was both safe and effective in establishing and maintaining sinus rhythm. (C) 2000 Elsevier Science B.V.
KW - Amiodarone
KW - Lung cancer
KW - Supraventricular arrhythmia
KW - Thoracotomy
UR - http://www.scopus.com/inward/record.url?scp=0034237741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034237741&partnerID=8YFLogxK
U2 - 10.1016/S1010-7940(00)00428-0
DO - 10.1016/S1010-7940(00)00428-0
M3 - Article
C2 - 10869934
AN - SCOPUS:0034237741
VL - 18
SP - 12
EP - 16
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
SN - 1010-7940
IS - 1
ER -