Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy

M. Sciacco, E. Scarpini, P. L. Baron, R. Doronzo, M. Moggio, D. Passerini, G. Scarlato

Research output: Contribution to journalArticle

Abstract

Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.

Original languageEnglish
Pages (from-to)547-553
Number of pages7
JournalActa Neuropathologica
Volume83
Issue number5
DOIs
Publication statusPublished - Apr 1992

Keywords

  • Electron microscopy
  • Immunohistochemistry
  • Localized hypertrophic neuropathy
  • Nerve growth factor receptor
  • Schwann cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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