Surface-activated chemical ionization and high-flow gradient chromatography to reduce matrix effect

Simone Cristoni, Luigi Rossi Bernardi, Piermario Gerthoux, Paolo Mocarelli, Maura Brambilla, Elisabetta Gonella, Federico Guidugli, Marco Cantu

Research output: Contribution to journalArticle

Abstract

The new atmospheric pressure chemical ionization source, named surface-activated chemical ionization (SACI), has been used in conjunction with high-flow gradient chromatography to reduce the matrix effect. This high-flow gradient chromatography approach avoids the co-elution of analyte and biological matrix compounds that leads to a reduction in quantitation errors due to matrix effect. However, this approach cannot be employed with the classical electrospray ionization (ESI) source that usually works at low eluent flow (

Original languageEnglish
Pages (from-to)2376-2382
Number of pages7
JournalRapid Communications in Mass Spectrometry
Volume20
Issue number16
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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  • Cite this

    Cristoni, S., Bernardi, L. R., Gerthoux, P., Mocarelli, P., Brambilla, M., Gonella, E., Guidugli, F., & Cantu, M. (2006). Surface-activated chemical ionization and high-flow gradient chromatography to reduce matrix effect. Rapid Communications in Mass Spectrometry, 20(16), 2376-2382. https://doi.org/10.1002/rcm.2599