Surface-activated chemical ionization ion trap mass spectrometry in the analysis of amphetamines in diluted urine samples

Simone Cristoni, Luigi Rossi Bernardi, Piermario Gerthoux, Elisabetta Gonella, Paolo Mocarelli

Research output: Contribution to journalArticle

Abstract

A new ionization method, named surface-activated chemical ionization (SACI), was employed for the analysis of five amphetamines (3,4- methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDE), amphetamine and methamphetamine) by ion trap mass spectrometry. The results so obtained have been compared with those achieved by using atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) using the same instrument, clearly showing that SACI is the most sensitive of the three. The limit of detection and linearity range for SACI were compared with those obtained using APCI and ESI, showing that the new SACI approach provides the best results for both criteria. SACI was used to analyze MDA, MDMA MDE, amphetamine and methamphetamine in four urine samples, and the quantitation results are compared with those achieved using ESI.

Original languageEnglish
Pages (from-to)1847-1855
Number of pages9
JournalRapid Communications in Mass Spectrometry
Volume18
Issue number16
DOIs
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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