Surface-activated no-discharge atmospheric pressure chemical ionization

Simone Cristoni, Luigi Rossi Bernardi, Ida Biunno, Michela Tubaro, Federico Guidugli

Research output: Contribution to journalArticlepeer-review


A new ionization method named surface-activated chemical ionization (SACI) has been realized. In this invention a commercially available atmospheric pressure chemical ionization (APCI) chamber, employed without any corona discharge (no-discharge APCI), has been modified with the insertion of a gold surface, leading to a significant improvement in the ionization efficiency. The ionization of the sample takes place by both gas-phase and surface-activated processes. This new ionization source is able to generate ions with high molecular mass and low charge states, leading to improved sensitivity and reduced noise. The new device has been tested in the analysis of some peptides. A comparison between the performance with and without the presence of the surface, and the optimization of the operating conditions (nebulizing gas flow, sample solution flow, pH of solution, and surface area), are reported and discussed.

Original languageEnglish
Pages (from-to)1973-1981
Number of pages9
JournalRapid Communications in Mass Spectrometry
Issue number17
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


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