Surface-based reconstruction and diffusion MRI in the assessment of gray and white matter damage in multiple sclerosis

Matteo Caffini, Niels Bergsland, Marcella Laganà, Eleonora Tavazzi, Paola Tortorella, Marco Rovaris, Giuseppe Baselli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Despite advances in the application of nonconventional MRI techniques in furthering the understanding of multiple sclerosis pathogenic mechanisms, there are still many unanswered questions, such as the relationship between gray and white matter damage. We applied a combination of advanced surface-based reconstruction and diffusion tensor imaging techniques to address this issue. We found significant relationships between white matter tract integrity indices and corresponding cortical structures. Our results suggest a direct link between damage in white and gray matter and contribute to the notion of gray matter loss relating to clinical disability.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9034
ISBN (Print)9780819498274
DOIs
Publication statusPublished - 2014
EventMedical Imaging 2014: Image Processing - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Other

OtherMedical Imaging 2014: Image Processing
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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    Caffini, M., Bergsland, N., Laganà, M., Tavazzi, E., Tortorella, P., Rovaris, M., & Baselli, G. (2014). Surface-based reconstruction and diffusion MRI in the assessment of gray and white matter damage in multiple sclerosis. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9034). [90343V] SPIE. https://doi.org/10.1117/12.2043268