Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler

Marco Morra, Gianluca Giavaresi, Maria Sartori, Andrea Ferrari, Annapaola Parrilli, Daniele Bollati, Ruggero Rodriguez Y Baena, Clara Cassinelli, Milena Fini

Research output: Contribution to journalArticlepeer-review


The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.

Original languageEnglish
JournalJournal of Materials Science: Materials in Medicine
Issue number4
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering


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