Abstract
The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
| Original language | English |
|---|---|
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Biophysics
- Biomaterials
- Bioengineering
- Biomedical Engineering
Cite this
Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler. / Morra, Marco; Giavaresi, Gianluca; Sartori, Maria; Ferrari, Andrea; Parrilli, Annapaola; Bollati, Daniele; Baena, Ruggero Rodriguez Y; Cassinelli, Clara; Fini, Milena.
In: Journal of Materials Science: Materials in Medicine, Vol. 26, No. 4, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler
AU - Morra, Marco
AU - Giavaresi, Gianluca
AU - Sartori, Maria
AU - Ferrari, Andrea
AU - Parrilli, Annapaola
AU - Bollati, Daniele
AU - Baena, Ruggero Rodriguez Y
AU - Cassinelli, Clara
AU - Fini, Milena
PY - 2015
Y1 - 2015
N2 - The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
AB - The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
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UR - http://www.scopus.com/inward/citedby.url?scp=84925275603&partnerID=8YFLogxK
U2 - 10.1007/s10856-015-5483-6
DO - 10.1007/s10856-015-5483-6
M3 - Article
C2 - 25786396
AN - SCOPUS:85000785460
VL - 26
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 4
ER -