Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler

Marco Morra, Gianluca Giavaresi, Maria Sartori, Andrea Ferrari, Annapaola Parrilli, Daniele Bollati, Ruggero Rodriguez Y Baena, Clara Cassinelli, Milena Fini

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.

Original languageEnglish
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

Biomimetics
Bone Regeneration
Surface chemistry
Fillers
Bone
Collagen
Bone and Bones
Surface analysis
Ceramics
Cell culture
Cell Communication
Cues
Minerals
Phosphates
Cell Culture Techniques
Rabbits
Equipment and Supplies
Defects

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler. / Morra, Marco; Giavaresi, Gianluca; Sartori, Maria; Ferrari, Andrea; Parrilli, Annapaola; Bollati, Daniele; Baena, Ruggero Rodriguez Y; Cassinelli, Clara; Fini, Milena.

In: Journal of Materials Science: Materials in Medicine, Vol. 26, No. 4, 2015.

Research output: Contribution to journalArticle

Morra, Marco ; Giavaresi, Gianluca ; Sartori, Maria ; Ferrari, Andrea ; Parrilli, Annapaola ; Bollati, Daniele ; Baena, Ruggero Rodriguez Y ; Cassinelli, Clara ; Fini, Milena. / Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler. In: Journal of Materials Science: Materials in Medicine. 2015 ; Vol. 26, No. 4.
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