Surface NK receptors and their ligands on tumor cells

Lorenzo Moretta; Cristina Bottino; Daniela Pende; Roberta Castriconi; Maria Cristina Mingari; Alessandro Moretta

doi:10.1016/j.smim.2006.03.002

Surface NK receptors and their ligands on tumor cells

Lorenzo Moretta, Cristina Bottino, Daniela Pende, Roberta Castriconi, Maria Cristina Mingari, Alessandro Moretta

Research output: Contribution to journal › Article › peer-review

Abstract

The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity. Thus, under pathological conditions, NK cells may express insufficient amounts of triggering receptors and target cells may or may not express ligands for such receptors. Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Seminars in Immunology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2006.03.002
Publication status	Published - Jun 2006

Keywords

Activating receptors
Cytolytic T lymphocytes
HLA-class I molecules
Inhibitory receptors
Killer Ig-like receptors
KIR repertoire
Natural killer cells

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Infectious Diseases

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title = "Surface NK receptors and their ligands on tumor cells",

abstract = "The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity. Thus, under pathological conditions, NK cells may express insufficient amounts of triggering receptors and target cells may or may not express ligands for such receptors. Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis.",

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AU - Moretta, Lorenzo

AU - Bottino, Cristina

AU - Pende, Daniela

AU - Castriconi, Roberta

AU - Mingari, Maria Cristina

AU - Moretta, Alessandro

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KW - KIR repertoire

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