Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

Eva V. Acosta-Rodriguez, Laura Rivino, Jens Geginat, David Jarrossay, Marco Gattorno, Antonio Lanzavecchia, Federica Sallusto, Giorgio Napolitani

Research output: Contribution to journalArticle

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Abstract

Interleukin 17 (IL-17)-producing T helper cells (TH-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORγt, a transcription factor, whereas CCR6 and CXCR3 identified TH1 cells producing interferon-γ and T helper cells producing both interferon-γ and IL-17. Memory T cells specific for Candida albicans were present mainly in the CCR6+CCR4+ TH-17 subset, whereas memory T cells specific for Mycobacterium tuberculosis were present in CCR6+CXCR3+ T helper type 1 subset. The elicitation of IL-17 responses correlated with the capacity of C. albicans hyphae to stimulate antigen-presenting cells for the priming of TH-17 responses in vitro and for the production of IL-23 but not IL-12. Our results demonstrate that human TH-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalNature Immunology
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 2007

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Interleukin-17
Helper-Inducer T-Lymphocytes
Epitopes
Phenotype
Th17 Cells
Candida albicans
T-Lymphocytes
Interferons
Fungal Antigens
Interleukin-23
Hyphae
Antigen-Presenting Cells
Interleukin-12
Mycobacterium tuberculosis
Cell Differentiation
Transcription Factors
Messenger RNA

ASJC Scopus subject areas

  • Immunology

Cite this

Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., ... Napolitani, G. (2007). Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nature Immunology, 8(6), 639-646. https://doi.org/10.1038/ni1467

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. / Acosta-Rodriguez, Eva V.; Rivino, Laura; Geginat, Jens; Jarrossay, David; Gattorno, Marco; Lanzavecchia, Antonio; Sallusto, Federica; Napolitani, Giorgio.

In: Nature Immunology, Vol. 8, No. 6, 06.2007, p. 639-646.

Research output: Contribution to journalArticle

Acosta-Rodriguez, EV, Rivino, L, Geginat, J, Jarrossay, D, Gattorno, M, Lanzavecchia, A, Sallusto, F & Napolitani, G 2007, 'Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells', Nature Immunology, vol. 8, no. 6, pp. 639-646. https://doi.org/10.1038/ni1467
Acosta-Rodriguez, Eva V. ; Rivino, Laura ; Geginat, Jens ; Jarrossay, David ; Gattorno, Marco ; Lanzavecchia, Antonio ; Sallusto, Federica ; Napolitani, Giorgio. / Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. In: Nature Immunology. 2007 ; Vol. 8, No. 6. pp. 639-646.
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