Surface wound healing: A new, general function of eukaryotic cells

J. Meldolesi

Research output: Contribution to journalArticlepeer-review


The ability to repair surface wounds is a property, necessary for long-term survival, expressed to various extents by all eukaryotic cell types except erythrocytes. The process is based on the rapid Ca2+-induced exocytosis of various types of specific organelles, such as lysosomes and enlargeosomes, that decreases surface tension and makes possible the spontaneous fusion of lipid monolayers at the lesion edges. The recognized importance of the process in physiology and in several cases of pathology is discussed.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Issue number3
Publication statusPublished - Jul 2003


  • Calcium
  • Enlargeosomes
  • Exocytosis
  • Lysosomes
  • Membrane repair
  • Membrane surface tension

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry


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