Il surfattante delle vie aeree. Rassegna critica e Ricerche personali

Translated title of the contribution: Surfactant and respiratory tract. A critical review and a personal contribution

E. Mira, M. Benazzo, F. De Paoli, A. Casasco, A. Calligaro

Research output: Contribution to journalArticle

Abstract

The literature proving the presence of a surface tension lowering substance (STLS) on the lining layer of mammalian Eustachian tube (ET) is critically reviewed. A further review of the chemical studies on tubal washings based on chromatographic analysis methods (TLC and HPLC) is performed, and is concluded that ET epithelium is coated by a mixture of phospholipids, similar but not identical to the pulmonary surfactant and with similar but less powerful surface activity. In both cases, and with minor differences between the different mammalian species, phosphatidylcholine (PC), and in particular its disaturated fraction, dipalmitoylphosphatidylcholine (DPPC), is the predominating and the most active compound. ET surfactant is synthesized by ET epithelium and secreted in form of osmiophilic multilamellar bodies into the tubal lumen. The exact function of the ET surfactant is not fully understood: it may play an important role in ET physiology by facilitating the tubal opening to allow for aeration of the middle ear and adequate drainage or could act as a release agent, preventing solid-to-solid adhesion of the tubal walls and contrasting the adhesive action of the glycoproteins of the mucous blanket. On the other hand a phospholipidic surfactant seems to be produced by the mucosa of the other parts of the upper airways, i.e. nose and trachea. In this case a surface active agent could act in preventing the transudation of serum into the lumen, in enhancing the phagocytosis or in facilitating the mucociliary transport. Recent data on humans, suggesting that a relative deficiency or an alterated production of tubal surfactant could play a role in the pathogenesis of secretory otitis media (SOM) or middle ear effusion (MEE), are reviewed. Administration of exogenous surfactant or pharmacological stimulation of the production of tubal surfactant could improve ET function and be of value in some cases of SOM. Personal data, suggesting that ambroxol (a drug stimulating the production of pulmonary surfactant by the alveolar type II pneumocytes) exerts a similar activating effect on the tubotympanal secretory cells, are reported. These data support the results of clinical studies on the treatment of SOM with ambroxol.

Original languageItalian
Pages (from-to)3-16
Number of pages14
JournalActa Otorhinolaryngologica Italica, Supplement
Volume17
Issue number56
Publication statusPublished - 1997

Fingerprint

Eustachian Tube
Surface-Active Agents
Respiratory System
Otitis Media with Effusion
Ambroxol
Pulmonary Surfactants
Epithelium
Alveolar Epithelial Cells
Mucociliary Clearance
1,2-Dipalmitoylphosphatidylcholine
Surface Tension
Middle Ear
Trachea
Phosphatidylcholines
Nose
Phagocytosis
Adhesives
Chromatography
Drainage
Phospholipids

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Il surfattante delle vie aeree. Rassegna critica e Ricerche personali. / Mira, E.; Benazzo, M.; De Paoli, F.; Casasco, A.; Calligaro, A.

In: Acta Otorhinolaryngologica Italica, Supplement, Vol. 17, No. 56, 1997, p. 3-16.

Research output: Contribution to journalArticle

Mira, E, Benazzo, M, De Paoli, F, Casasco, A & Calligaro, A 1997, 'Il surfattante delle vie aeree. Rassegna critica e Ricerche personali', Acta Otorhinolaryngologica Italica, Supplement, vol. 17, no. 56, pp. 3-16.
Mira, E. ; Benazzo, M. ; De Paoli, F. ; Casasco, A. ; Calligaro, A. / Il surfattante delle vie aeree. Rassegna critica e Ricerche personali. In: Acta Otorhinolaryngologica Italica, Supplement. 1997 ; Vol. 17, No. 56. pp. 3-16.
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