Surfactant protein B

From biochemistry to its potential role as diagnostic and prognostic marker in heart failure

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.

Original languageEnglish
Pages (from-to)456-462
Number of pages7
JournalInternational Journal of Cardiology
Volume221
DOIs
Publication statusPublished - Oct 15 2016

Fingerprint

Surface-Active Agents
Biochemistry
Heart Failure
Pulmonary Surfactant-Associated Proteins
Biomarkers
Alveolar Epithelial Cells
Pulmonary Surfactants
Membranes
Protein Isoforms
Proteins
Lung
IgA receptor

Keywords

  • Heart failure
  • Lung damage
  • Prognosis
  • Surfactant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Surfactant protein B: From biochemistry to its potential role as diagnostic and prognostic marker in heart failure",
abstract = "Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.",
keywords = "Heart failure, Lung damage, Prognosis, Surfactant",
author = "Cristina Banfi and Piergiuseppe Agostoni",
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T1 - Surfactant protein B

T2 - From biochemistry to its potential role as diagnostic and prognostic marker in heart failure

AU - Banfi, Cristina

AU - Agostoni, Piergiuseppe

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.

AB - Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.

KW - Heart failure

KW - Lung damage

KW - Prognosis

KW - Surfactant

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