Abstract
Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 456-462 |
| Number of pages | 7 |
| Journal | International Journal of Cardiology |
| Volume | 221 |
| DOIs | |
| Publication status | Published - Oct 15 2016 |
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Keywords
- Heart failure
- Lung damage
- Prognosis
- Surfactant
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Surfactant protein B : From biochemistry to its potential role as diagnostic and prognostic marker in heart failure. / Banfi, Cristina; Agostoni, Piergiuseppe.
In: International Journal of Cardiology, Vol. 221, 15.10.2016, p. 456-462.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Surfactant protein B
T2 - From biochemistry to its potential role as diagnostic and prognostic marker in heart failure
AU - Banfi, Cristina
AU - Agostoni, Piergiuseppe
PY - 2016/10/15
Y1 - 2016/10/15
N2 - Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.
AB - Growing interest raised on circulating biomarkers of structural alveolar–capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner. In the recent years circulating SP-B isoforms, mature or immature, have been demonstrated to be detectable in the circulation depending on the magnitude of the damage of alveolar capillary membrane. In the present review, we summarize the recent knowledge on SP-B regulation, function and we discuss its potential role as reliable biological marker of alveolar capillary membrane (dys)function in the context of heart failure.
KW - Heart failure
KW - Lung damage
KW - Prognosis
KW - Surfactant
UR - http://www.scopus.com/inward/record.url?scp=84978174731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978174731&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.07.003
DO - 10.1016/j.ijcard.2016.07.003
M3 - Review article
AN - SCOPUS:84978174731
VL - 221
SP - 456
EP - 462
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -