TY - JOUR
T1 - Surgery after radiochemotherapy for stage III lung cancer
T2 - Postoperative complications and late results
AU - Tavecchio, L.
AU - Ravasi, G.
AU - Bedini, A. V.
AU - Gramaglia, A.
AU - Milani, F.
PY - 1994
Y1 - 1994
N2 - Fifty-seven stage III lung cancer patients underwent radiochemotherapy and subsequent surgery. Forty radical (R -), six non-radical, and eleven exploratory operations were performed. Pneumonia (five cases), pulmonary insufficiency (one case), bronchial fistula (one case) were the major, non- fatal complications. Four deaths due to adult respiratory distress syndrome (ARDS) or pulmonary embolism occurred. Sixty percent of the 10 patients who had no viable tumor at operation survived 3 years, as well as 41% of those who achieved a complete remission by resection and 11% of those with residual disease (R+) after operation. However, the 1- and 2-year survival rates were similar. The main pattern of failure in R- and R+ patients was extra- and intra-RT-field progression, respectively. A slightly higher rate of postoperative complications, with respect to current practice, was observed. However, data lead to argument on the improvement of locoregional control and long-term survival following radical surgery.
AB - Fifty-seven stage III lung cancer patients underwent radiochemotherapy and subsequent surgery. Forty radical (R -), six non-radical, and eleven exploratory operations were performed. Pneumonia (five cases), pulmonary insufficiency (one case), bronchial fistula (one case) were the major, non- fatal complications. Four deaths due to adult respiratory distress syndrome (ARDS) or pulmonary embolism occurred. Sixty percent of the 10 patients who had no viable tumor at operation survived 3 years, as well as 41% of those who achieved a complete remission by resection and 11% of those with residual disease (R+) after operation. However, the 1- and 2-year survival rates were similar. The main pattern of failure in R- and R+ patients was extra- and intra-RT-field progression, respectively. A slightly higher rate of postoperative complications, with respect to current practice, was observed. However, data lead to argument on the improvement of locoregional control and long-term survival following radical surgery.
KW - combined treatments
KW - modality of failure
KW - post-treatment stage
KW - survival
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M3 - Article
C2 - 8176936
AN - SCOPUS:0028270505
VL - 56
SP - 2
EP - 6
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -