Surgery for acute graft-versu-host disease of the bowel: Description of a pediatric case

Maura Faraci, Sandro Dallorso, Guiseppe Morreale, Giorgio Dini, Elio Castagnola, Maurizio Miano, Monica Canepa, Antonino Rizzo, Girolamo Mattioli, Paolo Gandullia, Paolo Fiore, Carla Marino, Luca Manfredini, Edoardo Lanino

Research output: Contribution to journalArticlepeer-review

Abstract

Gastrointestinal acute graft-versus-host disease (GI-aGvHD) is still a common complication of allogeneic stem cell transplantation. Surgical management is an unusual approach, reserved for patients with intestinal occlusion, severe profuse rectal bleeding, or both. The authors describe a child with severe GI-aGvHD who did not respond to common immunosuppressive drugs and procedures and therefore underwent subtotal colectomy due to untreatable rectal bleeding. The bowel resection was followed by three "surgical looks" for occlusive intestinal episodes. In the end, a cholecystectomy for cholelithiasis was performed. The patient is still alive 41 months after stem cell transplantation, and although the terminal ileostomy is not closed yet, his quality of life is good. This experience suggests that surgery can be performed on children with severe, unresponsive GI-aGvHD.

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Bone marrow transplantation
  • Gastrointestinal acute graft-versus-host disease
  • Surgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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