Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role

Antonio Chiappa; Emilio Bertani; Andrew P. Zbar; Roberto Biffi; Francesca Biella; Massimo Bellomi; Giulia Zampino; Nicola Fazio; Davide Poldi; Ugo Page; Bruno Andreoni

Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role

Antonio Chiappa, Emilio Bertani, Andrew P. Zbar, Roberto Biffi, Francesca Biella, Massimo Bellomi, Giulia Zampino, Nicola Fazio, Davide Poldi, Ugo Page, Bruno Andreoni

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aims: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery. Methodology: Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were 70 years (group 2). Results: The overall peroperative mortality rate in younger patients was 0.8% (n=7), and 1.4% (n=3) in the elderly (p=NS); morbidity was 35% and 42%, respectively (p=NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p=0.03). Using logistic regression analysis, tumor stage (p<0.0001) and radicality of surgery (p

Original language	English
Pages (from-to)	740-745
Number of pages	6
Journal	Hepato-Gastroenterology
Volume	54
Issue number	75
Publication status	Published - Apr 2007

Keywords

Chemotherapy
Elderly
Postoperative mortality
Radiotherapy
Risk factors
Survival

ASJC Scopus subject areas

Gastroenterology

Cite this

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title = "Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role",

abstract = "Background/Aims: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery. Methodology: Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were 70 years (group 2). Results: The overall peroperative mortality rate in younger patients was 0.8% (n=7), and 1.4% (n=3) in the elderly (p=NS); morbidity was 35% and 42%, respectively (p=NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p=0.03). Using logistic regression analysis, tumor stage (p<0.0001) and radicality of surgery (p",

keywords = "Chemotherapy, Elderly, Postoperative mortality, Radiotherapy, Risk factors, Survival",

author = "Antonio Chiappa and Emilio Bertani and Zbar, {Andrew P.} and Roberto Biffi and Francesca Biella and Massimo Bellomi and Giulia Zampino and Nicola Fazio and Davide Poldi and Ugo Page and Bruno Andreoni",

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T1 - Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role

AU - Chiappa, Antonio

AU - Bertani, Emilio

AU - Zbar, Andrew P.

AU - Biffi, Roberto

AU - Biella, Francesca

AU - Bellomi, Massimo

AU - Zampino, Giulia

AU - Fazio, Nicola

AU - Poldi, Davide

AU - Page, Ugo

AU - Andreoni, Bruno

PY - 2007/4

Y1 - 2007/4

N2 - Background/Aims: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery. Methodology: Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were 70 years (group 2). Results: The overall peroperative mortality rate in younger patients was 0.8% (n=7), and 1.4% (n=3) in the elderly (p=NS); morbidity was 35% and 42%, respectively (p=NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p=0.03). Using logistic regression analysis, tumor stage (p<0.0001) and radicality of surgery (p

AB - Background/Aims: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery. Methodology: Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were 70 years (group 2). Results: The overall peroperative mortality rate in younger patients was 0.8% (n=7), and 1.4% (n=3) in the elderly (p=NS); morbidity was 35% and 42%, respectively (p=NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p=0.03). Using logistic regression analysis, tumor stage (p<0.0001) and radicality of surgery (p

KW - Chemotherapy

KW - Elderly

KW - Postoperative mortality

KW - Radiotherapy

KW - Risk factors

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Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role

Abstract

Keywords

ASJC Scopus subject areas

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