Surgical and Oncological Outcome of Robotic Surgery Compared with Laparoscopic and Abdominal Surgery in the Management of Locally Advanced Cervical Cancer after Neoadjuvant Chemotherapy

Giacomo Corrado, Giuseppe Cutillo, Maria Saltari, Emanuela Mancini, Stefano Sindico, Patrizia Vici, Domenico Sergi, Isabella Sperduti, Lodovico Patrizi, Giulia Pomati, Ermelinda Baiocco, Enrico Vizza

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The primary aim is to evaluate the surgical and oncological outcome of robotic radical hysterectomy (RRH) plus pelvic lymphadenectomy in locally advanced cervical cancer (LACC) after neoadjuvant chemotherapy (NACT). The secondary aim is to compare the surgical and oncological results of RRH after NACT with a historical cohort of patients undergoing laparoscopic radical hysterectomy or abdominal radical hysterectomy plus pelvic lymphadenectomy for LACC after NACT. Methods We enrolled a total of 41 patients in this study with LACC undergoing RRH, who achieved a clinical partial or complete response to NACT. The surgical and oncological outcomes of 2 historical groups were compared: the laparoscopic group (41 patients) with the laparotomic group (43 patients). Results The median estimated blood loss, operative time, and length of hospital stay were statistically significant and in favor of the robotic group. No conversion to laparotomy in the robotic group was necessary. There were no significant differences between the 3-year overall survival and disease-free survival rates in the minimally invasive groups; nevertheless, the robotic group showed the same recurrence rate of laparoscopic in a short-interval follow-up. Conclusions The robotic approach could be considered a feasible and safe alternative to other surgical options. Multicenter randomized clinical trials with longer follow-ups are necessary to evaluate the overall oncologic outcomes of this procedure.

Original languageEnglish
Pages (from-to)539-546
Number of pages8
JournalInternational Journal of Gynecological Cancer
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Locally advanced cervical cancer
  • Minimally invasive surgery
  • Neoadjuvant chemotherapy
  • Robot-assisted radical hysterectomy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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