Surgical excision of ovarian endometriomas: Does it truly impair ovarian reserve? Long term anti-Müllerian hormone (AMH) changes after surgery

Michele Vignali, Mohamed Mabrouk, Erika Ciocca, Giulia Alabiso, Allegra Barbasetti Di Prun, Davide Gentilini, Mauro Busacca

Research output: Contribution to journalArticle

Abstract

Aim The long-term effects of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral ovarian endometriomas were evaluated. Methods A total of 22 patients undergoing laparoscopic cystectomy for unilateral endometrioma (n-=-10) and bilateral endometriomas (n-=-12) were included in the study. Result(s) Serum anti-Müllerian hormone (AMH) levels significantly decreased from the baseline value (3.98-±-3.27 ng/mL) one (1.67-±-1.56 ng/mL), three (2.01-±-1.70 ng/mL), and six months (2.43-±-2.39 ng/mL) postoperatively. There was no difference between preoperative and 12 month postoperative AMH levels (4.01-±-3.39 ng/mL) (P->-0.05). Patients with bilateral endometriomas had a significantly higher rate of decline in AMH levels 12-months after surgery than patients with monolateral endometriomas (P-=-0.035), but in both groups there was no difference in AMH levels at one and 12-months postoperatively (P->-0.05). Conclusion(s) AMH levels temporarily decreased after laparoscopic cystectomy for ovarian endometriomas, with complete recovery of preoperative AMH values at 12-months postoperatively. This pattern was equal in patients with bilateral and unilateral ovarian involvement. Patients with bilateral cysts have higher rates of decline of AMH levels compared to patients with unilateral affection.

Original languageEnglish
Pages (from-to)1773-1778
Number of pages6
JournalJournal of Obstetrics and Gynaecology Research
Volume41
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • AMH
  • endometriosis
  • laparoscopy
  • ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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