Surgical impact of preoperative breast MRI in women below 40 years of age

Antonella Petrillo, Annamaria Porto, Roberta Fusco, Salvatore Filice, Paolo Vallone, Maria Rosaria Rubulotta, Franco Fulciniti, Maurizio Di Bonito, Massimiliano D'Aiuto, Immacolata Capasso, Rubina Manuela Trimboli, Francesco Sardanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Our aim was to evaluate the surgical impact of preoperative MRI in young patients. We reviewed a single-institution database of 283 consecutive patients below 40 years of age and who were treated for breast cancer. Thirty-seven (13 %) patients who received neoadjuvant chemotherapy were excluded. The remaining 246 patients included 124 (50 %) who preoperatively underwent conventional imaging (CI), i.e., mammography/ultrasonography (CI-group), and 122 (50 %) who underwent CI and dynamic MRI (CI + MRI-group). Pathology of surgical specimens served as a reference standard. Mann-Whitney, χ2, and McNemar statistics were used. There were no significant differences between groups in terms of age, tumor pathologic subtype, stage, receptor, or nodal status. The mastectomy rate was 111/246 (45 %) overall but was significantly different between groups (46/124, 37 %, for the CI group and 65/122, 53 %, for the CI + MRI group; p = 0.011). Of 122 CI + MRI patients, 46 (38 %) would have undergone mastectomy due to CI alone, while MRI determined 19 additional mastectomies, increasing the mastectomy rate from 38 % to 53 % (p 

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBreast Cancer Research and Treatment
DOIs
Publication statusAccepted/In press - 2013

Keywords

  • Breast cancer staging
  • Breast-conserving surgery
  • Mastectomy
  • MRI

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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